The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review
Objective:. In this review, we aim to provide an overview of literature on lymph node (LN) histomorphological features and their relationship with the prognosis in colorectal cancer (CRC). Background:. Lymph nodes play a crucial role in the treatment and prognosis of CRC. The presence of LN metastas...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2023-12-01
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| Series: | Annals of Surgery Open |
| Online Access: | http://journals.lww.com/10.1097/AS9.0000000000000336 |
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| author | Alexander J. Pennings, MSc Brecht A. van der Velden, BSc Maximilian Kloft, MSc Loes F. S. Kooreman, MSc Jos M. P. Kleijnen, PhD Stephanie O. Breukink, PhD Geerard L. Beets, PhD Heike I. Grabsch, PhD Jarno Melenhorst, PhD |
| author_facet | Alexander J. Pennings, MSc Brecht A. van der Velden, BSc Maximilian Kloft, MSc Loes F. S. Kooreman, MSc Jos M. P. Kleijnen, PhD Stephanie O. Breukink, PhD Geerard L. Beets, PhD Heike I. Grabsch, PhD Jarno Melenhorst, PhD |
| author_sort | Alexander J. Pennings, MSc |
| collection | DOAJ |
| description | Objective:. In this review, we aim to provide an overview of literature on lymph node (LN) histomorphological features and their relationship with the prognosis in colorectal cancer (CRC).
Background:. Lymph nodes play a crucial role in the treatment and prognosis of CRC. The presence of LN metastases considerably worsens the prognosis in CRC patients. Literature has shown that the total number of LNs and the number negative LNs (LNnegs) has prognostic value in CRC patients. In esophageal carcinoma, LN size seems to be surrogate of the host antitumor response and a potentially clinically useful new prognostic biomarker for (y)pN0 esophageal carcinoma.
Methods:. A comprehensive search was performed in Pubmed, Embase, Medline, CINAHL, and the Cochrane library in March 2021. The PRISMA guidelines were followed. Only studies focusing on histomorphological features and LN size and their relation to overall survival were selected.
Results:. A total of 9 unique articles met all inclusion criteria and were therefore included in this systematic review. Six of these studies investigated HMF (eg, paracortical hyperplasia, germinal center predominance, and sinus histiocytosis) and 4 studies LNneg size and their relationship with overall survival. The presence of paracortical hyperplasia and an increased number of large LNnegs is related to a more favorable prognosis in CRC.
Conclusion:. The results of this systematic review seem to support the hypothesis that there is a relationship between the host antitumor response reflected in different histomorphological reaction patterns visible in LNnegs and LNneg size related to survival in CRC patients. |
| format | Article |
| id | doaj-art-13b2c04384a84f0a8d786c601841088f |
| institution | Kabale University |
| issn | 2691-3593 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Annals of Surgery Open |
| spelling | doaj-art-13b2c04384a84f0a8d786c601841088f2025-01-24T09:18:12ZengWolters Kluwer HealthAnnals of Surgery Open2691-35932023-12-0144e33610.1097/AS9.0000000000000336202312000-00015The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic ReviewAlexander J. Pennings, MSc0Brecht A. van der Velden, BSc1Maximilian Kloft, MSc2Loes F. S. Kooreman, MSc3Jos M. P. Kleijnen, PhD4Stephanie O. Breukink, PhD5Geerard L. Beets, PhD6Heike I. Grabsch, PhD7Jarno Melenhorst, PhD8From the * Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands‡ NUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands§ Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands† GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands# Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the NetherlandsFrom the * Department of Surgery, Maastricht University Medical Center, Maastricht, the Netherlands† GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the Netherlands† GROW School for Oncology and Reproduction, Maastricht University, Maastricht, the NetherlandsFrom the * Department of Surgery, Maastricht University Medical Center, Maastricht, the NetherlandsObjective:. In this review, we aim to provide an overview of literature on lymph node (LN) histomorphological features and their relationship with the prognosis in colorectal cancer (CRC). Background:. Lymph nodes play a crucial role in the treatment and prognosis of CRC. The presence of LN metastases considerably worsens the prognosis in CRC patients. Literature has shown that the total number of LNs and the number negative LNs (LNnegs) has prognostic value in CRC patients. In esophageal carcinoma, LN size seems to be surrogate of the host antitumor response and a potentially clinically useful new prognostic biomarker for (y)pN0 esophageal carcinoma. Methods:. A comprehensive search was performed in Pubmed, Embase, Medline, CINAHL, and the Cochrane library in March 2021. The PRISMA guidelines were followed. Only studies focusing on histomorphological features and LN size and their relation to overall survival were selected. Results:. A total of 9 unique articles met all inclusion criteria and were therefore included in this systematic review. Six of these studies investigated HMF (eg, paracortical hyperplasia, germinal center predominance, and sinus histiocytosis) and 4 studies LNneg size and their relationship with overall survival. The presence of paracortical hyperplasia and an increased number of large LNnegs is related to a more favorable prognosis in CRC. Conclusion:. The results of this systematic review seem to support the hypothesis that there is a relationship between the host antitumor response reflected in different histomorphological reaction patterns visible in LNnegs and LNneg size related to survival in CRC patients.http://journals.lww.com/10.1097/AS9.0000000000000336 |
| spellingShingle | Alexander J. Pennings, MSc Brecht A. van der Velden, BSc Maximilian Kloft, MSc Loes F. S. Kooreman, MSc Jos M. P. Kleijnen, PhD Stephanie O. Breukink, PhD Geerard L. Beets, PhD Heike I. Grabsch, PhD Jarno Melenhorst, PhD The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review Annals of Surgery Open |
| title | The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review |
| title_full | The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review |
| title_fullStr | The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review |
| title_full_unstemmed | The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review |
| title_short | The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review |
| title_sort | role of nonmetastatic lymph nodes in the survival of colorectal cancer a systematic review |
| url | http://journals.lww.com/10.1097/AS9.0000000000000336 |
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