Characterization of neutralizing chimeric heavy-chain antibodies against tetanus toxin

Characterization of neutralizing chimeric heavy-chain antibodies against tetanus toxin

Tetanus toxin (TeNT) is one of the most toxic proteins. Neutralizing antibodies against TeNT are effective in prevention and treatment. In this study, 14 anti-tetanus nanobodies were obtained from a phage display nanobody library by immunizing a camel with the C-terminal receptor-binding domain of T...

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Bibliographic Details
Main Authors: Kexuan Cheng, Jiansheng Lu, Jiazheng Guo, Rong Wang, Lei Chen, Xi Wang, Yujia Jiang, Yating Li, Changyan Xu, Qinglin Kang, Gulisaina Qiaerxie, Peng Du, Chen Gao, Yunzhou Yu, Zhixin Yang, Wei Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Tetanus toxin
nanobody
heavy chain antibody
neutralizing antibody
phage display library
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2366641
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