Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation

Abstract Deubiquitinating enzymes (DUBs) are key regulators of cellular homoeostasis, and their dysregulation is associated with several human diseases. The ovarian tumour protease (OTU) family of DUBs are biochemically well-characterised and of therapeutic interest, yet only a few tool compounds ex...

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Bibliographic Details
Main Authors: Aini Vuorinen, Cassandra R. Kennedy, Katherine A. McPhie, William McCarthy, Jonathan Pettinger, J. Mark Skehel, David House, Jacob T. Bush, Katrin Rittinger
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01410-8
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