The Role of Placental Homeobox Genes in Human Fetal Growth Restriction
Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a n...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/548171 |
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| author | Padma Murthi Gayathri Rajaraman Shaun Patrick Brennecke Bill Kalionis |
| author_facet | Padma Murthi Gayathri Rajaraman Shaun Patrick Brennecke Bill Kalionis |
| author_sort | Padma Murthi |
| collection | DOAJ |
| description | Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR. |
| format | Article |
| id | doaj-art-1397e12ea8cf4a1fa5253b09542946fc |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-1397e12ea8cf4a1fa5253b09542946fc2025-02-03T01:20:14ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/548171548171The Role of Placental Homeobox Genes in Human Fetal Growth RestrictionPadma Murthi0Gayathri Rajaraman1Shaun Patrick Brennecke2Bill Kalionis3Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria 3010, AustraliaDepartment of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria 3010, AustraliaDepartment of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria 3010, AustraliaDepartment of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Victoria 3010, AustraliaFetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. One of the key causes of adverse pregnancy outcome is fetal growth restriction (FGR). While a number of maternal, fetal, and environmental factors are known causes of FGR, the majority of FGR cases remain idiopathic. These idiopathic FGR pregnancies are frequently associated with placental insufficiency, possibly as a result of placental maldevelopment. Understanding the molecular mechanisms of abnormal placental development in idiopathic FGR is, therefore, of increasing importance. Here, we review our understanding of transcriptional control of normal placental development and abnormal placental development associated with human idiopathic FGR. We also assess the potential for understanding transcriptional control as a means for revealing new molecular targets for the detection, diagnosis, and clinical management of idiopathic FGR.http://dx.doi.org/10.1155/2011/548171 |
| spellingShingle | Padma Murthi Gayathri Rajaraman Shaun Patrick Brennecke Bill Kalionis The Role of Placental Homeobox Genes in Human Fetal Growth Restriction Journal of Pregnancy |
| title | The Role of Placental Homeobox Genes in Human Fetal Growth Restriction |
| title_full | The Role of Placental Homeobox Genes in Human Fetal Growth Restriction |
| title_fullStr | The Role of Placental Homeobox Genes in Human Fetal Growth Restriction |
| title_full_unstemmed | The Role of Placental Homeobox Genes in Human Fetal Growth Restriction |
| title_short | The Role of Placental Homeobox Genes in Human Fetal Growth Restriction |
| title_sort | role of placental homeobox genes in human fetal growth restriction |
| url | http://dx.doi.org/10.1155/2011/548171 |
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