Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia
Introduction: Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests. Objective: Carry out epidemiological surveillance of the etiology of acute undifferentiat...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Travel Medicine and Infectious Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1477893925000067 |
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| author | Liliana Sánchez-Lerma Salim Mattar Verónica Contreras Jorge Miranda Vaneza Tique Virginia Rodríguez Derly Rodriguez Sonia Lopez Andrés Rojas-Gulloso |
| author_facet | Liliana Sánchez-Lerma Salim Mattar Verónica Contreras Jorge Miranda Vaneza Tique Virginia Rodríguez Derly Rodriguez Sonia Lopez Andrés Rojas-Gulloso |
| author_sort | Liliana Sánchez-Lerma |
| collection | DOAJ |
| description | Introduction: Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests. Objective: Carry out epidemiological surveillance of the etiology of acute undifferentiated febrile syndrome in the Meta department. Methods: A descriptive, prospective cross-sectional study was carried out between February 2021 and June 2023 in a first-level hospital in the department of Meta, Colombia. All enrolled patients underwent routine hematology and blood biochemistry examinations. RT-qPCR was performed for Dengue and serology for laboratory diagnoses using ELISA and MAT for Hantavirus and Leptospirosis, respectively. A descriptive and bivariate analysis was performed using SPSS vr 23.0. Results: Of the study's total of one hundred patients, 14 % showed antibodies against hantavirus IgG, of which two were seroconverted. In addition, a risk factor OR = 8.3 (CI = 1.8–38.4) for Hantavirus was found in those patients who had contact with farm animals. Regarding leptospirosis, 3 % of the sera agglutinated with titers greater than 1:400, resulting in a primary infection; 11 % of the sera presented agglutination with titers no greater than 1:200 as exposure to leptospirosis. The bivariate analysis showed an OR = 2.4; CI = 0.75–7.4 with water recreational activities in the last 30 days before the onset of symptoms. Conclusions: Our study demonstrates the importance of Hantavirus, Dengue, and leptospirosis as a cause of acute undifferentiated febrile illnesses. Coinfections are frequent in one of the tropical areas of Colombia, so it is crucial to establish a more precise diagnosis. |
| format | Article |
| id | doaj-art-13967929de274c02833da91daafb0f2f |
| institution | Kabale University |
| issn | 1873-0442 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Travel Medicine and Infectious Disease |
| spelling | doaj-art-13967929de274c02833da91daafb0f2f2025-01-29T05:00:22ZengElsevierTravel Medicine and Infectious Disease1873-04422025-03-0164102800Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, ColombiaLiliana Sánchez-Lerma0Salim Mattar1Verónica Contreras2Jorge Miranda3Vaneza Tique4Virginia Rodríguez5Derly Rodriguez6Sonia Lopez7Andrés Rojas-Gulloso8Universidad Cooperativa de Colombia, Facultad de Medicina. Grupo de investigación de Villavicencio-GRIVI, y Centro de Investigación en Salud para el Trópico, ColombiaUniversidad de Córdoba, Instituto de Investigaciones Biológicas del Trópico, Montería, Córdoba, Colombia; Corresponding author.Universidad de Córdoba, Instituto de Investigaciones Biológicas del Trópico, Montería, Córdoba, ColombiaUniversidad de Córdoba, Instituto de Investigaciones Biológicas del Trópico, Montería, Córdoba, ColombiaUniversidad de Córdoba, Instituto de Investigaciones Biológicas del Trópico, Montería, Córdoba, ColombiaUniversity of Cordoba, Faculty of Health Sciences, Department of Bacteriology, Research group GIMBIC. Monteria, Cordoba, ColombiaHospital Departamental de Villavicencio, Meta-Colombia, ColombiaUniversidad Cooperativa de Colombia, Facultad de Medicina. Grupo de investigación de Villavicencio-GRIVI, y Centro de Investigación en Salud para el Trópico, ColombiaUniversidad Cooperativa de Colombia, Facultad de Medicina. Grupo de investigación de Villavicencio-GRIVI, y Centro de Investigación en Salud para el Trópico, Colombia; Corresponding author.Introduction: Acute undifferentiated febrile illnesses are fevers lasting less than fourteen days without an evident focus of infection on the initial physical examination or with inconclusive laboratory tests. Objective: Carry out epidemiological surveillance of the etiology of acute undifferentiated febrile syndrome in the Meta department. Methods: A descriptive, prospective cross-sectional study was carried out between February 2021 and June 2023 in a first-level hospital in the department of Meta, Colombia. All enrolled patients underwent routine hematology and blood biochemistry examinations. RT-qPCR was performed for Dengue and serology for laboratory diagnoses using ELISA and MAT for Hantavirus and Leptospirosis, respectively. A descriptive and bivariate analysis was performed using SPSS vr 23.0. Results: Of the study's total of one hundred patients, 14 % showed antibodies against hantavirus IgG, of which two were seroconverted. In addition, a risk factor OR = 8.3 (CI = 1.8–38.4) for Hantavirus was found in those patients who had contact with farm animals. Regarding leptospirosis, 3 % of the sera agglutinated with titers greater than 1:400, resulting in a primary infection; 11 % of the sera presented agglutination with titers no greater than 1:200 as exposure to leptospirosis. The bivariate analysis showed an OR = 2.4; CI = 0.75–7.4 with water recreational activities in the last 30 days before the onset of symptoms. Conclusions: Our study demonstrates the importance of Hantavirus, Dengue, and leptospirosis as a cause of acute undifferentiated febrile illnesses. Coinfections are frequent in one of the tropical areas of Colombia, so it is crucial to establish a more precise diagnosis.http://www.sciencedirect.com/science/article/pii/S1477893925000067Emerging infectious diseasesEnvironmentPreventive medicine public healthDengue feverTropical climateDisease vector infectious |
| spellingShingle | Liliana Sánchez-Lerma Salim Mattar Verónica Contreras Jorge Miranda Vaneza Tique Virginia Rodríguez Derly Rodriguez Sonia Lopez Andrés Rojas-Gulloso Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia Travel Medicine and Infectious Disease Emerging infectious diseases Environment Preventive medicine public health Dengue fever Tropical climate Disease vector infectious |
| title | Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia |
| title_full | Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia |
| title_fullStr | Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia |
| title_full_unstemmed | Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia |
| title_short | Hantavirus and Leptospira are important causes of nonspecific acute febrile syndrome, Meta, Colombia |
| title_sort | hantavirus and leptospira are important causes of nonspecific acute febrile syndrome meta colombia |
| topic | Emerging infectious diseases Environment Preventive medicine public health Dengue fever Tropical climate Disease vector infectious |
| url | http://www.sciencedirect.com/science/article/pii/S1477893925000067 |
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