Dynamic Alternations in Mother–Infant Dyad’s Gut Microbiota over the Period of Six Months
Since birth, the human microbiome plays a pivotal role in health. It is intriguing to understand the establishing roles of intestinal microbiota in infants. This study aimed to investigate the dynamic changes in maternal and infant gut microbiota, the interaction between intestinal microbiota, and t...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/6/3239 |
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| Summary: | Since birth, the human microbiome plays a pivotal role in health. It is intriguing to understand the establishing roles of intestinal microbiota in infants. This study aimed to investigate the dynamic changes in maternal and infant gut microbiota, the interaction between intestinal microbiota, and the function of intestinal microbiota. This study recruited one pregnant woman >35 weeks gestational age. Faeces of the mother–infant dyad were regularly collected until the infant was six months old for metagenomic analysis. The results showed that the infant’s gut microbiota was significantly different from the mother’s, encompassing <i>Bacteroides fragilis</i>, <i>Ruminococcus gnavus, Klebsiella pneumoniae,</i> and <i>Klebsiella michiganensis</i>. Infant- or mother-specific differential metabolic pathways were found between the mother and infant’s gut microbiome, implicating differences in the intestinal metagenomic potential/function. In conclusion, the gut microbes and functions were gradually established as the infant grew. |
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| ISSN: | 2076-3417 |