Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults
G protein-coupled receptor kinase 4 (GRK4) with activating polymorphisms desensitize the natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly associated with salt sensitivity and hypertension. Meanwhile, N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/806810 |
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| author | Junichi Yatabe Midori S. Yatabe Minoru Yoneda Robin A. Felder Pedro A. Jose Hironobu Sanada |
| author_facet | Junichi Yatabe Midori S. Yatabe Minoru Yoneda Robin A. Felder Pedro A. Jose Hironobu Sanada |
| author_sort | Junichi Yatabe |
| collection | DOAJ |
| description | G protein-coupled receptor kinase 4 (GRK4) with activating polymorphisms desensitize the natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly associated with salt sensitivity and hypertension. Meanwhile, N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be useful in detecting slight volume expansion. However, relations between hypertension-related gene polymorphisms including GRK4 and cardiovascular indices such as NT-proBNP are not clear, especially in healthy subjects. Therefore, various hypertension-related polymorphisms and cardiovascular indices were analyzed in 97 normotensive, healthy Japanese adults. NT-proBNP levels were significantly higher in subjects with two or more GRK4 polymorphic alleles. Other hypertension-related gene polymorphisms, such as those of renin-angiotensin-aldosterone system genes, did not correlate with NT-proBNP. There was no significant association between any of the hypertension-related gene polymorphisms and central systolic blood pressure, cardioankle vascular index, augmentation index, plasma aldosterone concentration, or an oxidative stress marker, urinary 8-OHdG. Normotensive individuals with GRK4 polymorphisms show increased serum NT-proBNP concentration and may be at a greater risk of developing hypertension and cardiovascular disease. |
| format | Article |
| id | doaj-art-137cdc681b944c0a92cd1079f79bf539 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-137cdc681b944c0a92cd1079f79bf5392025-02-03T05:49:31ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/806810806810Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy AdultsJunichi Yatabe0Midori S. Yatabe1Minoru Yoneda2Robin A. Felder3Pedro A. Jose4Hironobu Sanada5Department of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University, School of Medicine, 1 Hikarigaoka Fukushima, Fukushima 960-1295, JapanDepartment of Nephrology, Hypertension, Diabetology, Endocrinology and Metabolism, Fukushima Medical University, School of Medicine, 1 Hikarigaoka Fukushima, Fukushima 960-1295, JapanDivision of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Fukushima, JapanDepartment of Pathology, University of Virginia Health System, Charlottesville, VA, USACenter for Molecular Physiology Research, Children’s National Medical Center and George Washington University, School of Medicine & Health Sciences, Washington, DC, USADivision of Health Science Research, Fukushima Welfare Federation of Agricultural Cooperatives, Fukushima, JapanG protein-coupled receptor kinase 4 (GRK4) with activating polymorphisms desensitize the natriuric renal tubular D1 dopamine receptor, and these GRK4 polymorphisms are strongly associated with salt sensitivity and hypertension. Meanwhile, N-terminal pro-B-type natriuretic peptide (NT-proBNP) may be useful in detecting slight volume expansion. However, relations between hypertension-related gene polymorphisms including GRK4 and cardiovascular indices such as NT-proBNP are not clear, especially in healthy subjects. Therefore, various hypertension-related polymorphisms and cardiovascular indices were analyzed in 97 normotensive, healthy Japanese adults. NT-proBNP levels were significantly higher in subjects with two or more GRK4 polymorphic alleles. Other hypertension-related gene polymorphisms, such as those of renin-angiotensin-aldosterone system genes, did not correlate with NT-proBNP. There was no significant association between any of the hypertension-related gene polymorphisms and central systolic blood pressure, cardioankle vascular index, augmentation index, plasma aldosterone concentration, or an oxidative stress marker, urinary 8-OHdG. Normotensive individuals with GRK4 polymorphisms show increased serum NT-proBNP concentration and may be at a greater risk of developing hypertension and cardiovascular disease.http://dx.doi.org/10.1155/2012/806810 |
| spellingShingle | Junichi Yatabe Midori S. Yatabe Minoru Yoneda Robin A. Felder Pedro A. Jose Hironobu Sanada Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults International Journal of Hypertension |
| title | Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults |
| title_full | Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults |
| title_fullStr | Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults |
| title_full_unstemmed | Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults |
| title_short | Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults |
| title_sort | hypertension related gene polymorphisms of g protein coupled receptor kinase 4 are associated with nt probnp concentration in normotensive healthy adults |
| url | http://dx.doi.org/10.1155/2012/806810 |
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