Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease
The demand for drug delivery systems (DDS) to treat Parkinson’s disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. Herbal products for PD have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration. Here, we attempt...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2022/9150205 |
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| author | Delna Joy Jobin Jose Shabana Bibi Akshay Bandiwadekar Gopika Gopan Clara Mariana Gonçalves Lima Talha Bin Emran Fahad A. Alhumaydhi Harsha Ashtekar Sandeep D. S Carlos Adam Conte-Junior |
| author_facet | Delna Joy Jobin Jose Shabana Bibi Akshay Bandiwadekar Gopika Gopan Clara Mariana Gonçalves Lima Talha Bin Emran Fahad A. Alhumaydhi Harsha Ashtekar Sandeep D. S Carlos Adam Conte-Junior |
| author_sort | Delna Joy |
| collection | DOAJ |
| description | The demand for drug delivery systems (DDS) to treat Parkinson’s disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. Herbal products for PD have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration. Here, we attempted to incorporate solid lipid nanoparticles (SLNs) of Bacopa monnieri into dissolvable microneedle arrays and evaluate its neuroprotective activity. The bloodless and painless microneedle arrays through the transdermal route deliver the drug across the blood-brain barrier at the desired concentration. The quality by design (QbD) approach was employed for optimizing the SLNs formulations. The mechanical strength, in vitro release studies, ex-vivo permeation investigation, skin irritation test, histopathological studies, biochemical studies, and behavioural tests SLNs loaded microneedle arrays were performed. The microneedle patches obtained were shown to be mechanically robust and were also found to be nonirritant with a decreased degree of bradykinesia, high motor coordination, and balance ability. Compared to systemic delivery systems, such an MN method can achieve a considerably lower effective dose and allow long-term home-based treatment. |
| format | Article |
| id | doaj-art-13748a6567f44e74b389b2b1071027e7 |
| institution | Kabale University |
| issn | 1687-479X |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-13748a6567f44e74b389b2b1071027e72025-02-03T05:57:24ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/9150205Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s DiseaseDelna Joy0Jobin Jose1Shabana Bibi2Akshay Bandiwadekar3Gopika Gopan4Clara Mariana Gonçalves Lima5Talha Bin Emran6Fahad A. Alhumaydhi7Harsha Ashtekar8Sandeep D. S9Carlos Adam Conte-Junior10NITTE Deemed-to-be UniversityNITTE Deemed-to-be UniversityYunnan Herbal LaboratoryNITTE Deemed-to-be UniversityNITTE Deemed-to-be UniversityDepartment of Food ScienceDepartment of PharmacyDepartment of Medical LaboratoriesNITTE Deemed-to-be UniversityNITTE Deemed-to-be UniversityCenter for Food Analysis (NAL)The demand for drug delivery systems (DDS) to treat Parkinson’s disease (PD) is still high, and microneedle (MN) assisted transdermal DDS offers enormous potential. Herbal products for PD have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration. Here, we attempted to incorporate solid lipid nanoparticles (SLNs) of Bacopa monnieri into dissolvable microneedle arrays and evaluate its neuroprotective activity. The bloodless and painless microneedle arrays through the transdermal route deliver the drug across the blood-brain barrier at the desired concentration. The quality by design (QbD) approach was employed for optimizing the SLNs formulations. The mechanical strength, in vitro release studies, ex-vivo permeation investigation, skin irritation test, histopathological studies, biochemical studies, and behavioural tests SLNs loaded microneedle arrays were performed. The microneedle patches obtained were shown to be mechanically robust and were also found to be nonirritant with a decreased degree of bradykinesia, high motor coordination, and balance ability. Compared to systemic delivery systems, such an MN method can achieve a considerably lower effective dose and allow long-term home-based treatment.http://dx.doi.org/10.1155/2022/9150205 |
| spellingShingle | Delna Joy Jobin Jose Shabana Bibi Akshay Bandiwadekar Gopika Gopan Clara Mariana Gonçalves Lima Talha Bin Emran Fahad A. Alhumaydhi Harsha Ashtekar Sandeep D. S Carlos Adam Conte-Junior Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease Bioinorganic Chemistry and Applications |
| title | Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease |
| title_full | Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease |
| title_fullStr | Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease |
| title_full_unstemmed | Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease |
| title_short | Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease |
| title_sort | development of microneedle patch loaded with bacopa monnieri solid lipid nanoparticles for the effective management of parkinson s disease |
| url | http://dx.doi.org/10.1155/2022/9150205 |
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