Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats
Background and aimsObesity is a disease associated with increased oxidative stress in humans and animals, and consumption of antioxidant compounds such as polyphenols can minimise it. These compounds are abundant in malícia (Mimosa quadrivalvis L.) honey produced by stingless bees. This study aimed...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1524642/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087307067326464 |
|---|---|
| author | Maria Luiza Rolim Bezerra Maria Luiza Rolim Bezerra Mirela Gouveia-Nhanca Mirela Gouveia-Nhanca Maria Letícia da Veiga Dutra Maria Letícia da Veiga Dutra Kamila Sabino Batista Alana Natalícia Vasconcelos de Araújo Alana Natalícia Vasconcelos de Araújo Marcos dos Santos Lima Marcos dos Santos Lima Mateus Duarte Ribeiro Mateus Duarte Ribeiro Alexandre Sergio Silva Alexandre Sergio Silva Alexandre Sergio Silva Adriano Francisco Alves Tatiana Colombo Pimentel Marciane Magnani Marciane Magnani Jailane de Souza Aquino Jailane de Souza Aquino Jailane de Souza Aquino |
| author_facet | Maria Luiza Rolim Bezerra Maria Luiza Rolim Bezerra Mirela Gouveia-Nhanca Mirela Gouveia-Nhanca Maria Letícia da Veiga Dutra Maria Letícia da Veiga Dutra Kamila Sabino Batista Alana Natalícia Vasconcelos de Araújo Alana Natalícia Vasconcelos de Araújo Marcos dos Santos Lima Marcos dos Santos Lima Mateus Duarte Ribeiro Mateus Duarte Ribeiro Alexandre Sergio Silva Alexandre Sergio Silva Alexandre Sergio Silva Adriano Francisco Alves Tatiana Colombo Pimentel Marciane Magnani Marciane Magnani Jailane de Souza Aquino Jailane de Souza Aquino Jailane de Souza Aquino |
| author_sort | Maria Luiza Rolim Bezerra |
| collection | DOAJ |
| description | Background and aimsObesity is a disease associated with increased oxidative stress in humans and animals, and consumption of antioxidant compounds such as polyphenols can minimise it. These compounds are abundant in malícia (Mimosa quadrivalvis L.) honey produced by stingless bees. This study aimed to evaluate whether administration of Mimosa quadrivalvis L. honey to obese rats could reduce oxidative stress in vital organs through phenolic compound action.MethodsWistar rats (228 ± 14.69 g) were randomly divided into two groups: a healthy group (HG, n = 20) fed a control diet and an obese group (OG, n = 20) fed a cafeteria diet for the initial 8 weeks. After this period, these groups were again randomised into four subgroups: healthy (HG, n = 10), obese (OG, n = 10), healthy with malícia honey administration (1,000 mg/kg; HGH, n = 10), and obese with malícia honey administration (1,000 mg/kg; OGH, n = 10) for the final 8 weeks fed the previously mentioned diets. The rats were euthanised at the end of the experiment to collect brain, gut, kidney, and liver tissues to evaluate parameters related to oxidative stress and phenolic profile.ResultsThe administration of malícia honey reduced energy intake and weight gain in the OGH in comparison to the OG. Total antioxidant capacity increased in the brain, liver, and gut in both groups treated with honey compared to respective controls. Lipid peroxidation decreased in the brain, gut, and kidney of the OGH. Both treated groups showed elevated phenolic compound deposition, including catechin, procyanidins, and flavonoids, across all organs. Specifically, the brain in the OGH showed greater procyanidin B2 and gallic acid deposition; the liver showed increased procyanidin B1 and B2, epicatechin, and myricetin concentrations; the gut showed higher procyanidin B2 and kaempferol 3-glucoside concentrations; and the kidneys had increased catechin, procyanidin B1 and B2, and gallic acid deposition compared to the OG.ConclusionHistologically, the OGH displayed reduced neuronal damage and prevention of hepatic steatosis induced by the cafeteria diet. Malícia honey effectively reduced oxidative stress via modulation of phenolic compounds in the brain, gut, kidney, and liver of cafeteria diet-induced obese rats. |
| format | Article |
| id | doaj-art-1357c080dfe34be09e389dae1ccb4d18 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-1357c080dfe34be09e389dae1ccb4d182025-02-06T05:21:45ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-02-011210.3389/fnut.2025.15246421524642Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese ratsMaria Luiza Rolim Bezerra0Maria Luiza Rolim Bezerra1Mirela Gouveia-Nhanca2Mirela Gouveia-Nhanca3Maria Letícia da Veiga Dutra4Maria Letícia da Veiga Dutra5Kamila Sabino Batista6Alana Natalícia Vasconcelos de Araújo7Alana Natalícia Vasconcelos de Araújo8Marcos dos Santos Lima9Marcos dos Santos Lima10Mateus Duarte Ribeiro11Mateus Duarte Ribeiro12Alexandre Sergio Silva13Alexandre Sergio Silva14Alexandre Sergio Silva15Adriano Francisco Alves16Tatiana Colombo Pimentel17Marciane Magnani18Marciane Magnani19Jailane de Souza Aquino20Jailane de Souza Aquino21Jailane de Souza Aquino22Experimental Nutrition Laboratory—LANEX, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilExperimental Nutrition Laboratory—LANEX, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilExperimental Nutrition Laboratory—LANEX, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilSemi Arid National Institute (INSA), Campina Grande, BrazilExperimental Nutrition Laboratory—LANEX, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilDepartment of Food Technology, Instituto Federal do Sertão Pernambucano (IFSertãoPE), Petrolina, BrazilPost Graduate Program in Food Sciences and Technology, Federal University of Paraíba (UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health (LETFADS), Department of Physical Education, Federal University of Paraíba (UFPB), João Pessoa, BrazilAssociate Post Graduate Program in Physical Education (UPE/UFPB), Department of Physical Education, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health (LETFADS), Department of Physical Education, Federal University of Paraíba (UFPB), João Pessoa, BrazilAssociate Post Graduate Program in Physical Education (UPE/UFPB), Department of Physical Education, Federal University of Paraíba (UFPB), João Pessoa, BrazilLaboratory of General Pathology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, BrazilInstituto Federal do Paraná (IFPR), Campus Paranavaí, Paranavaí, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Food Sciences and Technology, Federal University of Paraíba (UFPB), João Pessoa, BrazilExperimental Nutrition Laboratory—LANEX, Department of Nutrition, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Nutrition Sciences, Federal University of Paraíba (UFPB), João Pessoa, BrazilPost Graduate Program in Food Sciences and Technology, Federal University of Paraíba (UFPB), João Pessoa, BrazilBackground and aimsObesity is a disease associated with increased oxidative stress in humans and animals, and consumption of antioxidant compounds such as polyphenols can minimise it. These compounds are abundant in malícia (Mimosa quadrivalvis L.) honey produced by stingless bees. This study aimed to evaluate whether administration of Mimosa quadrivalvis L. honey to obese rats could reduce oxidative stress in vital organs through phenolic compound action.MethodsWistar rats (228 ± 14.69 g) were randomly divided into two groups: a healthy group (HG, n = 20) fed a control diet and an obese group (OG, n = 20) fed a cafeteria diet for the initial 8 weeks. After this period, these groups were again randomised into four subgroups: healthy (HG, n = 10), obese (OG, n = 10), healthy with malícia honey administration (1,000 mg/kg; HGH, n = 10), and obese with malícia honey administration (1,000 mg/kg; OGH, n = 10) for the final 8 weeks fed the previously mentioned diets. The rats were euthanised at the end of the experiment to collect brain, gut, kidney, and liver tissues to evaluate parameters related to oxidative stress and phenolic profile.ResultsThe administration of malícia honey reduced energy intake and weight gain in the OGH in comparison to the OG. Total antioxidant capacity increased in the brain, liver, and gut in both groups treated with honey compared to respective controls. Lipid peroxidation decreased in the brain, gut, and kidney of the OGH. Both treated groups showed elevated phenolic compound deposition, including catechin, procyanidins, and flavonoids, across all organs. Specifically, the brain in the OGH showed greater procyanidin B2 and gallic acid deposition; the liver showed increased procyanidin B1 and B2, epicatechin, and myricetin concentrations; the gut showed higher procyanidin B2 and kaempferol 3-glucoside concentrations; and the kidneys had increased catechin, procyanidin B1 and B2, and gallic acid deposition compared to the OG.ConclusionHistologically, the OGH displayed reduced neuronal damage and prevention of hepatic steatosis induced by the cafeteria diet. Malícia honey effectively reduced oxidative stress via modulation of phenolic compounds in the brain, gut, kidney, and liver of cafeteria diet-induced obese rats.https://www.frontiersin.org/articles/10.3389/fnut.2025.1524642/fullcafeteria dietobesityoxidative stressphenolic compoundsstingless bee honey |
| spellingShingle | Maria Luiza Rolim Bezerra Maria Luiza Rolim Bezerra Mirela Gouveia-Nhanca Mirela Gouveia-Nhanca Maria Letícia da Veiga Dutra Maria Letícia da Veiga Dutra Kamila Sabino Batista Alana Natalícia Vasconcelos de Araújo Alana Natalícia Vasconcelos de Araújo Marcos dos Santos Lima Marcos dos Santos Lima Mateus Duarte Ribeiro Mateus Duarte Ribeiro Alexandre Sergio Silva Alexandre Sergio Silva Alexandre Sergio Silva Adriano Francisco Alves Tatiana Colombo Pimentel Marciane Magnani Marciane Magnani Jailane de Souza Aquino Jailane de Souza Aquino Jailane de Souza Aquino Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats Frontiers in Nutrition cafeteria diet obesity oxidative stress phenolic compounds stingless bee honey |
| title | Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats |
| title_full | Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats |
| title_fullStr | Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats |
| title_full_unstemmed | Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats |
| title_short | Malícia honey (Mimosa quadrivalvis L.) produced by the jandaíra bee (Melipona subnitida D.) shows antioxidant activity via phenolic compound action in obese rats |
| title_sort | malicia honey mimosa quadrivalvis l produced by the jandaira bee melipona subnitida d shows antioxidant activity via phenolic compound action in obese rats |
| topic | cafeteria diet obesity oxidative stress phenolic compounds stingless bee honey |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1524642/full |
| work_keys_str_mv | AT marialuizarolimbezerra maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marialuizarolimbezerra maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT mirelagouveianhanca maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT mirelagouveianhanca maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marialeticiadaveigadutra maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marialeticiadaveigadutra maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT kamilasabinobatista maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT alananataliciavasconcelosdearaujo maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT alananataliciavasconcelosdearaujo maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marcosdossantoslima maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marcosdossantoslima maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT mateusduarteribeiro maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT mateusduarteribeiro maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT alexandresergiosilva maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT alexandresergiosilva maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT alexandresergiosilva maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT adrianofranciscoalves maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT tatianacolombopimentel maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marcianemagnani maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT marcianemagnani maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT jailanedesouzaaquino maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT jailanedesouzaaquino maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats AT jailanedesouzaaquino maliciahoneymimosaquadrivalvislproducedbythejandairabeemeliponasubnitidadshowsantioxidantactivityviaphenoliccompoundactioninobeserats |