Factors associated with early-onset androgenetic alopecia: A scoping review.
<h4>Background</h4>Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to e...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299212&type=printable |
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| author | Li-Ping Liu Mary Adumo Wariboko Xiao Hu Zi-Han Wang Qian Wu Yu-Mei Li |
| author_facet | Li-Ping Liu Mary Adumo Wariboko Xiao Hu Zi-Han Wang Qian Wu Yu-Mei Li |
| author_sort | Li-Ping Liu |
| collection | DOAJ |
| description | <h4>Background</h4>Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA.<h4>Methods</h4>Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL. Eligible studies included case-control, cohort, cross-sectional, and meta-analysis studies. Selected studies needed to clearly define early-onset AGA cases or include only cases starting before the age of 40 and compare them with appropriate controls. The exclusion criteria comprised editorials, commentaries, case series, and non-systematic reviews, among others. Data extraction involved collecting study characteristics, methodologies, main outcomes, and findings. Descriptive tables were used to summarize key information and relevant variables when necessary.<h4>Results</h4>Among the 65 eligible articles, 67.69% were case-control studies and 78.46% evaluated only male patients. "Early-onset" was defined as cases developing before the age of 30 years in 43.08% of the studies. The Hamilton-Norwood scale was the most frequently used method for evaluating the severity of alopecia in men (69.23%). Reported risk factors for early-onset AGA included a family history of AGA, cigarette smoking, unhealthy dietary habits, and a high body mass index. Early-onset AGA may also be associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and some susceptibility loci. Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson's disease. Men with early-onset AGA may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. Additionally, young men with AGA tended to suffer from psychological issues such as anxiety and low self-esteem compared to those without hair loss.<h4>Conclusion</h4>Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and psychological health. |
| format | Article |
| id | doaj-art-13504f89946f48d2971af80682f3f540 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-13504f89946f48d2971af80682f3f5402025-02-05T05:32:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e029921210.1371/journal.pone.0299212Factors associated with early-onset androgenetic alopecia: A scoping review.Li-Ping LiuMary Adumo WaribokoXiao HuZi-Han WangQian WuYu-Mei Li<h4>Background</h4>Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA.<h4>Methods</h4>Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL. Eligible studies included case-control, cohort, cross-sectional, and meta-analysis studies. Selected studies needed to clearly define early-onset AGA cases or include only cases starting before the age of 40 and compare them with appropriate controls. The exclusion criteria comprised editorials, commentaries, case series, and non-systematic reviews, among others. Data extraction involved collecting study characteristics, methodologies, main outcomes, and findings. Descriptive tables were used to summarize key information and relevant variables when necessary.<h4>Results</h4>Among the 65 eligible articles, 67.69% were case-control studies and 78.46% evaluated only male patients. "Early-onset" was defined as cases developing before the age of 30 years in 43.08% of the studies. The Hamilton-Norwood scale was the most frequently used method for evaluating the severity of alopecia in men (69.23%). Reported risk factors for early-onset AGA included a family history of AGA, cigarette smoking, unhealthy dietary habits, and a high body mass index. Early-onset AGA may also be associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and some susceptibility loci. Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson's disease. Men with early-onset AGA may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. Additionally, young men with AGA tended to suffer from psychological issues such as anxiety and low self-esteem compared to those without hair loss.<h4>Conclusion</h4>Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and psychological health.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299212&type=printable |
| spellingShingle | Li-Ping Liu Mary Adumo Wariboko Xiao Hu Zi-Han Wang Qian Wu Yu-Mei Li Factors associated with early-onset androgenetic alopecia: A scoping review. PLoS ONE |
| title | Factors associated with early-onset androgenetic alopecia: A scoping review. |
| title_full | Factors associated with early-onset androgenetic alopecia: A scoping review. |
| title_fullStr | Factors associated with early-onset androgenetic alopecia: A scoping review. |
| title_full_unstemmed | Factors associated with early-onset androgenetic alopecia: A scoping review. |
| title_short | Factors associated with early-onset androgenetic alopecia: A scoping review. |
| title_sort | factors associated with early onset androgenetic alopecia a scoping review |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299212&type=printable |
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