Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density
ABSTRACT Purpose Metabolic dysfunction–associated steatohepatitis (MASH) is a prevalent disease caused by high fat and high cholesterol intake, which leads to systemic deterioration. The aim of this research is to conduct a psychobiological exploration of MASH in adult male rats. Methods Subjects wh...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70222 |
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| author | Sara G. Higarza Marina De Antón‐Cosío Candela Zorzo Jorge L. Arias Natalia Arias |
| author_facet | Sara G. Higarza Marina De Antón‐Cosío Candela Zorzo Jorge L. Arias Natalia Arias |
| author_sort | Sara G. Higarza |
| collection | DOAJ |
| description | ABSTRACT Purpose Metabolic dysfunction–associated steatohepatitis (MASH) is a prevalent disease caused by high fat and high cholesterol intake, which leads to systemic deterioration. The aim of this research is to conduct a psychobiological exploration of MASH in adult male rats. Methods Subjects who were administered a high‐fat and high‐cholesterol diet for 14 weeks. Then, we assessed the acoustic startle response and alertness through the prepulse inhibition paradigm as well as the associative learning by the use of the passive avoidance test. Also, we explored the astrocyte density in the prefrontal cortex and hippocampus. Results Our results showed that, whereas the MASH group did not display an impaired associative learning, a lower exploration rate was found in this group. Moreover, a reduced prepulse inhibition was found in these subjects in the case of the weaker and closer‐to‐the‐stimulus prepulse, which indicates a mild alteration in this process. No differences were found in astrocyte density in the MASH group in comparison with controls. Conclusion MASH seems to be linked with cognitive dysfunction. Further research is needed to elucidate the pathway involved in this disease and its underlying mechanism, as well as the potential implication in human health. |
| format | Article |
| id | doaj-art-134e33e1d652409894bc05f20aadf939 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-134e33e1d652409894bc05f20aadf9392025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70222Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte DensitySara G. Higarza0Marina De Antón‐Cosío1Candela Zorzo2Jorge L. Arias3Natalia Arias4INEUROPA, Instituto de Neurociencias del Principado de Asturias Oviedo SpainNeuroscience Laboratory, Department of Psychology University of Oviedo Oviedo SpainINEUROPA, Instituto de Neurociencias del Principado de Asturias Oviedo SpainINEUROPA, Instituto de Neurociencias del Principado de Asturias Oviedo SpainINEUROPA, Instituto de Neurociencias del Principado de Asturias Oviedo SpainABSTRACT Purpose Metabolic dysfunction–associated steatohepatitis (MASH) is a prevalent disease caused by high fat and high cholesterol intake, which leads to systemic deterioration. The aim of this research is to conduct a psychobiological exploration of MASH in adult male rats. Methods Subjects who were administered a high‐fat and high‐cholesterol diet for 14 weeks. Then, we assessed the acoustic startle response and alertness through the prepulse inhibition paradigm as well as the associative learning by the use of the passive avoidance test. Also, we explored the astrocyte density in the prefrontal cortex and hippocampus. Results Our results showed that, whereas the MASH group did not display an impaired associative learning, a lower exploration rate was found in this group. Moreover, a reduced prepulse inhibition was found in these subjects in the case of the weaker and closer‐to‐the‐stimulus prepulse, which indicates a mild alteration in this process. No differences were found in astrocyte density in the MASH group in comparison with controls. Conclusion MASH seems to be linked with cognitive dysfunction. Further research is needed to elucidate the pathway involved in this disease and its underlying mechanism, as well as the potential implication in human health.https://doi.org/10.1002/brb3.70222astrocytesmetabolic dysfunction–associated steatohepatitispassive avoidanceprepulse inhibition |
| spellingShingle | Sara G. Higarza Marina De Antón‐Cosío Candela Zorzo Jorge L. Arias Natalia Arias Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density Brain and Behavior astrocytes metabolic dysfunction–associated steatohepatitis passive avoidance prepulse inhibition |
| title | Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density |
| title_full | Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density |
| title_fullStr | Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density |
| title_full_unstemmed | Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density |
| title_short | Effects of Metabolic Dysfunction–Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density |
| title_sort | effects of metabolic dysfunction associated steatohepatitis in alertness associative learning and astrocyte density |
| topic | astrocytes metabolic dysfunction–associated steatohepatitis passive avoidance prepulse inhibition |
| url | https://doi.org/10.1002/brb3.70222 |
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