IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/686597 |
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| _version_ | 1832561407799853056 |
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| author | Robert B. Ashman Dipti Vijayan Christine A. Wells |
| author_facet | Robert B. Ashman Dipti Vijayan Christine A. Wells |
| author_sort | Robert B. Ashman |
| collection | DOAJ |
| description | IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them. |
| format | Article |
| id | doaj-art-133e1e03fa744b8a9a19b1466b6619eb |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-133e1e03fa744b8a9a19b1466b6619eb2025-02-03T01:25:05ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/686597686597IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans InfectionRobert B. Ashman0Dipti Vijayan1Christine A. Wells2The School of Dentistry, University of Queensland School of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, AustraliaThe National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, AustraliaThe National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, AustraliaIL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.http://dx.doi.org/10.1155/2011/686597 |
| spellingShingle | Robert B. Ashman Dipti Vijayan Christine A. Wells IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection Clinical and Developmental Immunology |
| title | IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection |
| title_full | IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection |
| title_fullStr | IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection |
| title_full_unstemmed | IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection |
| title_short | IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection |
| title_sort | il 12 and related cytokines function and regulatory implications in candida albicans infection |
| url | http://dx.doi.org/10.1155/2011/686597 |
| work_keys_str_mv | AT robertbashman il12andrelatedcytokinesfunctionandregulatoryimplicationsincandidaalbicansinfection AT diptivijayan il12andrelatedcytokinesfunctionandregulatoryimplicationsincandidaalbicansinfection AT christineawells il12andrelatedcytokinesfunctionandregulatoryimplicationsincandidaalbicansinfection |