Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators
Tendon disorders—tendinopathies—are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations. Whilst the molecular pathophysiology of tendinopathy remains difficult to interpret the disease process involving repetitive stress, and...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/436203 |
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| author | Neal L. Millar George A. C. Murrell |
| author_facet | Neal L. Millar George A. C. Murrell |
| author_sort | Neal L. Millar |
| collection | DOAJ |
| description | Tendon disorders—tendinopathies—are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations. Whilst the molecular pathophysiology of tendinopathy remains difficult to interpret the disease process involving repetitive stress, and cellular load provides important mechanistic insight into the area of heat shock proteins which spans many disease processes in the autoimmune community. Heat shock proteins, also called damage-associated molecular patterns (DAMPs), are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue. Our investigations have highlighted a key role for HSPs in tendion disease which may ultimately affect tissue rescue mechanisms in tendon pathology. This paper aims to provide an overview of the biology of heat shock proteins in soft tissue and how these mediators may be important regulators of inflammatory mediators and matrix regulation in tendinopathy. |
| format | Article |
| id | doaj-art-130482699be244e280762716cabb7ea6 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-130482699be244e280762716cabb7ea62025-02-03T05:50:09ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/436203436203Heat Shock Proteins in Tendinopathy: Novel Molecular RegulatorsNeal L. Millar0George A. C. Murrell1Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UKDepartment of Orthopaedic Surgery, Orthopaedic Research Institute, University of New South Wales, St. George Hospital Campus, Kogarah, Sydney, NSW 2217, AustraliaTendon disorders—tendinopathies—are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations. Whilst the molecular pathophysiology of tendinopathy remains difficult to interpret the disease process involving repetitive stress, and cellular load provides important mechanistic insight into the area of heat shock proteins which spans many disease processes in the autoimmune community. Heat shock proteins, also called damage-associated molecular patterns (DAMPs), are rapidly released following nonprogrammed cell death, are key effectors of the innate immune system, and critically restore homeostasis by promoting the reconstruction of the effected tissue. Our investigations have highlighted a key role for HSPs in tendion disease which may ultimately affect tissue rescue mechanisms in tendon pathology. This paper aims to provide an overview of the biology of heat shock proteins in soft tissue and how these mediators may be important regulators of inflammatory mediators and matrix regulation in tendinopathy.http://dx.doi.org/10.1155/2012/436203 |
| spellingShingle | Neal L. Millar George A. C. Murrell Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators Mediators of Inflammation |
| title | Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators |
| title_full | Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators |
| title_fullStr | Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators |
| title_full_unstemmed | Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators |
| title_short | Heat Shock Proteins in Tendinopathy: Novel Molecular Regulators |
| title_sort | heat shock proteins in tendinopathy novel molecular regulators |
| url | http://dx.doi.org/10.1155/2012/436203 |
| work_keys_str_mv | AT neallmillar heatshockproteinsintendinopathynovelmolecularregulators AT georgeacmurrell heatshockproteinsintendinopathynovelmolecularregulators |