A Rare Sequela of Acute Disseminated Encephalomyelitis
Acute disseminated encephalomyelitis is a demyelinating disease, typically occurring in children following a febrile infection or a vaccination. Primary and secondary immune responses contribute to inflammation and subsequent demyelination, but the exact pathogenesis is still unknown. Diagnosis of a...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/291380 |
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| author | Vijay Kodadhala Saravana Devulapalli Mohankumar Kurukumbi Annapurni Jayam-Trouth |
| author_facet | Vijay Kodadhala Saravana Devulapalli Mohankumar Kurukumbi Annapurni Jayam-Trouth |
| author_sort | Vijay Kodadhala |
| collection | DOAJ |
| description | Acute disseminated encephalomyelitis is a demyelinating disease, typically occurring in children following a febrile infection or a vaccination. Primary and secondary immune responses contribute to inflammation and subsequent demyelination, but the exact pathogenesis is still unknown. Diagnosis of acute disseminated encephalomyelitis is strongly suggested by temporal relationship between an infection or an immunization and the onset of neurological symptoms. Biopsy is definitive. In general, the disease is self-limiting and the prognostic outcome is favorable with anti-inflammatory and immunosuppressive agents. Locked-in syndrome describes patients who are awake and conscious but have no means of producing limb, speech, or facial movements. Locked-in syndrome is a rare complication of acute disseminated encephalomyelitis. We present a case of incomplete locked-in syndrome occurring in a 34-year-old male secondary to acute disseminated encephalomyelitis. Our case is unique, as acute disseminated encephalomyelitis occurred in a 34-year-old which was poorly responsive to immunosuppression resulting in severe disability. |
| format | Article |
| id | doaj-art-12fa77e31f964d36a65e19e537a4e0b6 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-12fa77e31f964d36a65e19e537a4e0b62025-02-03T05:59:28ZengWileyCase Reports in Neurological Medicine2090-66682090-66762014-01-01201410.1155/2014/291380291380A Rare Sequela of Acute Disseminated EncephalomyelitisVijay Kodadhala0Saravana Devulapalli1Mohankumar Kurukumbi2Annapurni Jayam-Trouth3Department of Internal Medicine, Howard University Hospital, Washington, DC 20060, USADepartment of Neurology, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USADepartment of Neurology, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USADepartment of Neurology, Howard University Hospital, 2041 Georgia Avenue, Washington, DC 20060, USAAcute disseminated encephalomyelitis is a demyelinating disease, typically occurring in children following a febrile infection or a vaccination. Primary and secondary immune responses contribute to inflammation and subsequent demyelination, but the exact pathogenesis is still unknown. Diagnosis of acute disseminated encephalomyelitis is strongly suggested by temporal relationship between an infection or an immunization and the onset of neurological symptoms. Biopsy is definitive. In general, the disease is self-limiting and the prognostic outcome is favorable with anti-inflammatory and immunosuppressive agents. Locked-in syndrome describes patients who are awake and conscious but have no means of producing limb, speech, or facial movements. Locked-in syndrome is a rare complication of acute disseminated encephalomyelitis. We present a case of incomplete locked-in syndrome occurring in a 34-year-old male secondary to acute disseminated encephalomyelitis. Our case is unique, as acute disseminated encephalomyelitis occurred in a 34-year-old which was poorly responsive to immunosuppression resulting in severe disability.http://dx.doi.org/10.1155/2014/291380 |
| spellingShingle | Vijay Kodadhala Saravana Devulapalli Mohankumar Kurukumbi Annapurni Jayam-Trouth A Rare Sequela of Acute Disseminated Encephalomyelitis Case Reports in Neurological Medicine |
| title | A Rare Sequela of Acute Disseminated Encephalomyelitis |
| title_full | A Rare Sequela of Acute Disseminated Encephalomyelitis |
| title_fullStr | A Rare Sequela of Acute Disseminated Encephalomyelitis |
| title_full_unstemmed | A Rare Sequela of Acute Disseminated Encephalomyelitis |
| title_short | A Rare Sequela of Acute Disseminated Encephalomyelitis |
| title_sort | rare sequela of acute disseminated encephalomyelitis |
| url | http://dx.doi.org/10.1155/2014/291380 |
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