Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy
Immunotherapy, including immune checkpoint inhibitors, tumor vaccine therapy, oncolytic virotherapy, and adoptive cell therapy, has made remarkably breakthroughs in the field of oncology. Immune checkpoint inhibitors, which block programmed death receptor 1 or programmed death ligand 1, have been in...
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| Format: | Article |
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Magazine House of Cancer Research on Prevention and Treatment
2025-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0839 |
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| author | Yufan CHEN Sicong LI Yiyuan CUI Li FENG |
| author_facet | Yufan CHEN Sicong LI Yiyuan CUI Li FENG |
| author_sort | Yufan CHEN |
| collection | DOAJ |
| description | Immunotherapy, including immune checkpoint inhibitors, tumor vaccine therapy, oncolytic virotherapy, and adoptive cell therapy, has made remarkably breakthroughs in the field of oncology. Immune checkpoint inhibitors, which block programmed death receptor 1 or programmed death ligand 1, have been included in the first-line clinical treatment for advanced solid tumors, such as non-small cell lung cancer and malignant melanoma. However, primary or secondary drug resistance in tumors severely limits the survival benefits for patients. Immune-related adverse reactions, such as pneumonia, hypothyroidism, hypophysitis, and myocarditis, also greatly affect the quality of life of patients. Fuzheng Jiedu Huayu is an important concept guiding the prevention and treatment of tumors with traditional Chinese medicine (TCM). It is also a curative principle and therapeutic TCM method to reduce the toxicity and enhance the efficacy of immunotherapy. This article summarizes the research progress of immunotherapy and discusses how TCM reduces the toxicity and enhances the efficacy of immunotherapy, hoping to provide a reference for the integrated treatment of tumors with TCM and immunotherapy. |
| format | Article |
| id | doaj-art-12f97a5d8054487a8213b35f908ea6a7 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-12f97a5d8054487a8213b35f908ea6a72025-01-23T07:44:48ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-01-01521111810.3971/j.issn.1000-8578.2025.24.083920240839Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of ImmunotherapyYufan CHEN0Sicong LI1Yiyuan CUI2Li FENG3Department of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy for Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy for Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy for Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Traditional Chinese Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy for Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaImmunotherapy, including immune checkpoint inhibitors, tumor vaccine therapy, oncolytic virotherapy, and adoptive cell therapy, has made remarkably breakthroughs in the field of oncology. Immune checkpoint inhibitors, which block programmed death receptor 1 or programmed death ligand 1, have been included in the first-line clinical treatment for advanced solid tumors, such as non-small cell lung cancer and malignant melanoma. However, primary or secondary drug resistance in tumors severely limits the survival benefits for patients. Immune-related adverse reactions, such as pneumonia, hypothyroidism, hypophysitis, and myocarditis, also greatly affect the quality of life of patients. Fuzheng Jiedu Huayu is an important concept guiding the prevention and treatment of tumors with traditional Chinese medicine (TCM). It is also a curative principle and therapeutic TCM method to reduce the toxicity and enhance the efficacy of immunotherapy. This article summarizes the research progress of immunotherapy and discusses how TCM reduces the toxicity and enhances the efficacy of immunotherapy, hoping to provide a reference for the integrated treatment of tumors with TCM and immunotherapy.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0839malignant tumortraditional chinese medicinereduce toxicity and enhance efficiencyimmunotherapy |
| spellingShingle | Yufan CHEN Sicong LI Yiyuan CUI Li FENG Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy Zhongliu Fangzhi Yanjiu malignant tumor traditional chinese medicine reduce toxicity and enhance efficiency immunotherapy |
| title | Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy |
| title_full | Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy |
| title_fullStr | Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy |
| title_full_unstemmed | Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy |
| title_short | Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy |
| title_sort | research progress of fuzheng jiedu huayu method in reducing toxicity and enhancing efficacy of immunotherapy |
| topic | malignant tumor traditional chinese medicine reduce toxicity and enhance efficiency immunotherapy |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0839 |
| work_keys_str_mv | AT yufanchen researchprogressoffuzhengjieduhuayumethodinreducingtoxicityandenhancingefficacyofimmunotherapy AT sicongli researchprogressoffuzhengjieduhuayumethodinreducingtoxicityandenhancingefficacyofimmunotherapy AT yiyuancui researchprogressoffuzhengjieduhuayumethodinreducingtoxicityandenhancingefficacyofimmunotherapy AT lifeng researchprogressoffuzhengjieduhuayumethodinreducingtoxicityandenhancingefficacyofimmunotherapy |