A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index
Background Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low‐income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.14343 |
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| author | Amin Mansoori Mina Nosrati Mohsen Dorchin Fatemeh Mohammadyari Elahe Derakhshan‐Nezhad Gordon Ferns Habibollah Esmaily Majid Ghayour‐Mobarhan |
| author_facet | Amin Mansoori Mina Nosrati Mohsen Dorchin Fatemeh Mohammadyari Elahe Derakhshan‐Nezhad Gordon Ferns Habibollah Esmaily Majid Ghayour‐Mobarhan |
| author_sort | Amin Mansoori |
| collection | DOAJ |
| description | Background Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low‐income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index which is derived from fasting state. In this study we aimed to compare the accuracy of with CHG index and triglycerides (TG) and glucose levels (TyG) as surrogates of type 2 diabetes mellitus. Methods A total of 9,704 individuals between 35 and 65 years of age were recruited as part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. They were categorized into two groups, those with and without type 2 diabetes mellitus. The cut‐off in groups to detection of type 2 diabetes mellitus was fasting blood glucose ≥126 mg/dL in blood sample. Receiver operating characteristic (ROC) curve analysis was used to establish the cut‐off of indices to evaluate the sensitivity and specificity of them. Results The best cut‐off of CHG index for diagnosis of type 2 diabetes mellitus was 5.57 which was associated with a sensitivity of 70.38% and specificity of 89.82% values. This was in comparison to the TyG index. LR+ CHG index was 6.91 compared to 3.47 for the TyG index and the AUC of CHG index was 0.864 (0.857, 0.871) compared with 0.825 (0.818, 0.833) for the TyG index. This indicates that the CHG index has a higher efficiency value to diagnose of type 2 diabetes mellitus. Conclusions The CHG index could be useful for the detection of type 2 diabetes mellitus. |
| format | Article |
| id | doaj-art-12f8113b324349bdb30818778e22928b |
| institution | Kabale University |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-12f8113b324349bdb30818778e22928b2025-02-01T10:02:01ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-02-0116230931410.1111/jdi.14343A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) indexAmin Mansoori0Mina Nosrati1Mohsen Dorchin2Fatemeh Mohammadyari3Elahe Derakhshan‐Nezhad4Gordon Ferns5Habibollah Esmaily6Majid Ghayour‐Mobarhan7Department of Applied Mathematics Ferdowsi University of Mashhad Mashhad IranInternational UNESCO Center for Health‐Related Basic Sciences and Human Nutrition Mashhad University of Medical Sciences Mashhad IranDepartment of Nutrition, School of Medicine Mashhad University of Medical Sciences Mashhad IranSchool of Medicine Guilan University of Medical Sciences Rasht IranStudent Research Committee Mashhad University of Medical Sciences Mashhad IranDivision of Medical Education Brighton and Sussex Medical School Brighton UKDepartment of Biostatistics, School of Health Mashhad University of Medical Sciences Mashhad IranDepartment of Nutrition, School of Medicine Mashhad University of Medical Sciences Mashhad IranBackground Gold standard methods of type 2 diabetes mellitus are expensive and therefore not practical for large scale studies in low‐income countries. We have investigated the total cholesterol, high density lipoprotein (HDL), and glucose (CHG) index for diagnosis of type 2 diabetes mellitus index which is derived from fasting state. In this study we aimed to compare the accuracy of with CHG index and triglycerides (TG) and glucose levels (TyG) as surrogates of type 2 diabetes mellitus. Methods A total of 9,704 individuals between 35 and 65 years of age were recruited as part of the Mashhad stroke and heart atherosclerotic disorder (MASHAD) study. They were categorized into two groups, those with and without type 2 diabetes mellitus. The cut‐off in groups to detection of type 2 diabetes mellitus was fasting blood glucose ≥126 mg/dL in blood sample. Receiver operating characteristic (ROC) curve analysis was used to establish the cut‐off of indices to evaluate the sensitivity and specificity of them. Results The best cut‐off of CHG index for diagnosis of type 2 diabetes mellitus was 5.57 which was associated with a sensitivity of 70.38% and specificity of 89.82% values. This was in comparison to the TyG index. LR+ CHG index was 6.91 compared to 3.47 for the TyG index and the AUC of CHG index was 0.864 (0.857, 0.871) compared with 0.825 (0.818, 0.833) for the TyG index. This indicates that the CHG index has a higher efficiency value to diagnose of type 2 diabetes mellitus. Conclusions The CHG index could be useful for the detection of type 2 diabetes mellitus.https://doi.org/10.1111/jdi.14343CHG indexTyG indexType 2 Diabetes Mellitus |
| spellingShingle | Amin Mansoori Mina Nosrati Mohsen Dorchin Fatemeh Mohammadyari Elahe Derakhshan‐Nezhad Gordon Ferns Habibollah Esmaily Majid Ghayour‐Mobarhan A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index Journal of Diabetes Investigation CHG index TyG index Type 2 Diabetes Mellitus |
| title | A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index |
| title_full | A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index |
| title_fullStr | A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index |
| title_full_unstemmed | A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index |
| title_short | A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index |
| title_sort | novel index for diagnosis of type 2 diabetes mellitus cholesterol high density lipoprotein and glucose chg index |
| topic | CHG index TyG index Type 2 Diabetes Mellitus |
| url | https://doi.org/10.1111/jdi.14343 |
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