Inflammatory signaling pathways play a role in SYK inhibitor resistant AML

Inflammatory signaling pathways play a role in SYK inhibitor resistant AML

Abstract Trials have shown promising clinical activity of the selective SYK inhibitor entospletinib in patients with high expressing HOXA9/MEIS1 acute leukemias. As the development of resistance mechanisms is a common problem in the use of targeted drugs, we performed a chemical library screen to id...

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Bibliographic Details
Main Authors: Sarah Tausch, Christina Villinger, Gabriela Alexe, Daniel J. Urban, Min Shen, Dominique Jahn, Jonas Vischedyk, Sebastian Scheich, Hubert Serve, Matthew D. Hall, Kimberly Stegmaier, Thomas Oellerich, Anjali Cremer
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Acute myeloid leukemia cells
Resistance
Inflammatory pathways
Glucocorticoids
Online Access:https://doi.org/10.1038/s41598-025-96660-w
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