Current status and perspectives of esophageal cancer: a comprehensive review

Abstract Esophageal cancer (EC) continues to be a significant global health concern, with two main subtypes: esophageal squamous cell carcinoma and esophageal adenocarcinoma. Prevention and changes in etiology, improvements in early detection, and refinements in the treatment have led to remarkable...

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Bibliographic Details
Main Authors: Wei Jiang, Bo Zhang, Jiaqi Xu, Liyan Xue, Luhua Wang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Cancer Communications
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Online Access:https://doi.org/10.1002/cac2.12645
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Summary:Abstract Esophageal cancer (EC) continues to be a significant global health concern, with two main subtypes: esophageal squamous cell carcinoma and esophageal adenocarcinoma. Prevention and changes in etiology, improvements in early detection, and refinements in the treatment have led to remarkable progress in the outcomes of EC patients in the past two decades. This seminar provides an in‐depth analysis of advances in the epidemiology, disease biology, screening, diagnosis, and treatment landscape of esophageal cancer, focusing on the ongoing debate surrounding multimodality therapy. Despite significant advancements, EC remains a deadly disease, underscoring the need for continued research into early detection methods, understanding the molecular mechanisms, and developing effective treatments.
ISSN:2523-3548