Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study
Aim. Delirium is common among mechanically ventilated patients in the intensive care unit (ICU). There are little data regarding delirium among mechanically ventilated patients in Africa. We sought to determine the burden of delirium and associated factors in Uganda. Methods. We conducted a multicen...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/491780 |
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| author | Arthur Kwizera Jane Nakibuuka Lameck Ssemogerere Charles Sendikadiwa Daniel Obua Samuel Kizito Janat Tumukunde Agnes Wabule Noeline Nakasujja |
| author_facet | Arthur Kwizera Jane Nakibuuka Lameck Ssemogerere Charles Sendikadiwa Daniel Obua Samuel Kizito Janat Tumukunde Agnes Wabule Noeline Nakasujja |
| author_sort | Arthur Kwizera |
| collection | DOAJ |
| description | Aim. Delirium is common among mechanically ventilated patients in the intensive care unit (ICU). There are little data regarding delirium among mechanically ventilated patients in Africa. We sought to determine the burden of delirium and associated factors in Uganda. Methods. We conducted a multicenter prospective study among mechanically ventilated patients in Uganda. Eligible patients were screened daily for delirium using the confusional assessment method (CAM-ICU). Comparisons were made using t-test, chi-squares, and Fisher’s exact test. Predictors were assessed using logistic regression. The level of statistical significance was set at P<0.05. Results. Of 160 patients, 81 (51%) had delirium. Median time to onset of delirium was 3.7 days. At bivariate analysis, history of mental illness, sedation, multiorgan dysfunction, neurosurgery, tachypnea, low mean arterial pressure, oliguria, fevers, metabolic acidosis, respiratory acidosis, anaemia, physical restraints, marital status, and endotracheal tube use were significant predictors. At multivariable analysis, having a history of mental illness, sedation, respiratory acidosis, higher PEEP, endotracheal tubes, and anaemia predicted delirium. Conclusion. The prevalence of delirium in a young African population is lower than expected considering the high mortality. A history of mental illness, anaemia, sedation, endotracheal tube use, and respiratory acidosis were factors associated with delirium. |
| format | Article |
| id | doaj-art-12cebe71f3bf4e7f87d8a834bbd60ad7 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-12cebe71f3bf4e7f87d8a834bbd60ad72025-08-20T03:54:20ZengWileyCritical Care Research and Practice2090-13052090-13132015-01-01201510.1155/2015/491780491780Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter StudyArthur Kwizera0Jane Nakibuuka1Lameck Ssemogerere2Charles Sendikadiwa3Daniel Obua4Samuel Kizito5Janat Tumukunde6Agnes Wabule7Noeline Nakasujja8Department of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Internal Medicine, Mulago Hospital Complex, Mulago Hill, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Internal Medicine, Mulago Hospital Complex, Mulago Hill, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Clinical Epidemiology and Biostatistics, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Anaesthesia, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaDepartment of Psychiatry, Makerere University College of Health Sciences, Mulago National Referral Hospital, P.O. Box 7051, Kampala, UgandaAim. Delirium is common among mechanically ventilated patients in the intensive care unit (ICU). There are little data regarding delirium among mechanically ventilated patients in Africa. We sought to determine the burden of delirium and associated factors in Uganda. Methods. We conducted a multicenter prospective study among mechanically ventilated patients in Uganda. Eligible patients were screened daily for delirium using the confusional assessment method (CAM-ICU). Comparisons were made using t-test, chi-squares, and Fisher’s exact test. Predictors were assessed using logistic regression. The level of statistical significance was set at P<0.05. Results. Of 160 patients, 81 (51%) had delirium. Median time to onset of delirium was 3.7 days. At bivariate analysis, history of mental illness, sedation, multiorgan dysfunction, neurosurgery, tachypnea, low mean arterial pressure, oliguria, fevers, metabolic acidosis, respiratory acidosis, anaemia, physical restraints, marital status, and endotracheal tube use were significant predictors. At multivariable analysis, having a history of mental illness, sedation, respiratory acidosis, higher PEEP, endotracheal tubes, and anaemia predicted delirium. Conclusion. The prevalence of delirium in a young African population is lower than expected considering the high mortality. A history of mental illness, anaemia, sedation, endotracheal tube use, and respiratory acidosis were factors associated with delirium.http://dx.doi.org/10.1155/2015/491780 |
| spellingShingle | Arthur Kwizera Jane Nakibuuka Lameck Ssemogerere Charles Sendikadiwa Daniel Obua Samuel Kizito Janat Tumukunde Agnes Wabule Noeline Nakasujja Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study Critical Care Research and Practice |
| title | Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study |
| title_full | Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study |
| title_fullStr | Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study |
| title_full_unstemmed | Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study |
| title_short | Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study |
| title_sort | incidence and risk factors for delirium among mechanically ventilated patients in an african intensive care setting an observational multicenter study |
| url | http://dx.doi.org/10.1155/2015/491780 |
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