Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes
The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and inve...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/4375253 |
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| author | Wen Cao Ren-Dong Zheng Shu-Hang Xu Yao-Fu Fan Hong-Ping Sun Chao Liu |
| author_facet | Wen Cao Ren-Dong Zheng Shu-Hang Xu Yao-Fu Fan Hong-Ping Sun Chao Liu |
| author_sort | Wen Cao |
| collection | DOAJ |
| description | The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum creatinine, and HOMA-IR levels. SUA, waist circumference, BMI, and HOMA-IR showed a negative correlation with TT level, while age showed a positive correlation with TT level. SUA and body mass index were found to be risk factors for gonadal dysfunction. Therefore, we conclude that hypogonadism of male patients with T2DM is related to SUA level. |
| format | Article |
| id | doaj-art-12ccefffc6a64af186a1ec0481e733a7 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-12ccefffc6a64af186a1ec0481e733a72025-02-03T01:10:16ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/43752534375253Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 DiabetesWen Cao0Ren-Dong Zheng1Shu-Hang Xu2Yao-Fu Fan3Hong-Ping Sun4Chao Liu5The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210013, ChinaEndocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, ChinaEndocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, ChinaEndocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, ChinaEndocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, ChinaEndocrine and Diabetes Center, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, ChinaThe association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum creatinine, and HOMA-IR levels. SUA, waist circumference, BMI, and HOMA-IR showed a negative correlation with TT level, while age showed a positive correlation with TT level. SUA and body mass index were found to be risk factors for gonadal dysfunction. Therefore, we conclude that hypogonadism of male patients with T2DM is related to SUA level.http://dx.doi.org/10.1155/2017/4375253 |
| spellingShingle | Wen Cao Ren-Dong Zheng Shu-Hang Xu Yao-Fu Fan Hong-Ping Sun Chao Liu Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes International Journal of Endocrinology |
| title | Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes |
| title_full | Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes |
| title_fullStr | Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes |
| title_full_unstemmed | Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes |
| title_short | Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes |
| title_sort | association between sex hormone and blood uric acid in male patients with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2017/4375253 |
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