Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center
Background: Adult T-cell leukemia/lymphoma (ATL) is a neoplasm with a high prevalence in certain regions such as southwestern Japan, the Caribbean, sub-Saharan Africa, South America, and Australia. In Colombia, the seroprevalence of human T-cell lymphotropic virus type 1 (HTLV-1) has been reported i...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-02-01
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| Series: | Therapeutic Advances in Hematology |
| Online Access: | https://doi.org/10.1177/20406207251316178 |
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| author | Danielle Floyd-Aristizábal Cristian Alonso Barreiro García Oriana Arias-Valderrama Catalina Proaño Millán Nhora María Silva Perez Joaquín Donaldo Rosales Martinez Elizabeth Arrieta López |
| author_facet | Danielle Floyd-Aristizábal Cristian Alonso Barreiro García Oriana Arias-Valderrama Catalina Proaño Millán Nhora María Silva Perez Joaquín Donaldo Rosales Martinez Elizabeth Arrieta López |
| author_sort | Danielle Floyd-Aristizábal |
| collection | DOAJ |
| description | Background: Adult T-cell leukemia/lymphoma (ATL) is a neoplasm with a high prevalence in certain regions such as southwestern Japan, the Caribbean, sub-Saharan Africa, South America, and Australia. In Colombia, the seroprevalence of human T-cell lymphotropic virus type 1 (HTLV-1) has been reported in specific populations, but there is limited information about the clinical course and management of ATL in the country. Objectives: To describe the clinical characteristics, treatment patterns, and outcomes of patients diagnosed with HTLV-1-positive ATL in a high-complexity healthcare institution in Colombia and compare these findings with reports from other geographic regions. Design: Observational retrospective cohort study conducted in a single high-complexity healthcare institution in Cali, Colombia, including patients diagnosed between 2011 and January 2022. Methods: This study presents an observational retrospective cohort of patients diagnosed with HTLV-1-positive ATL and managed at a high-complexity institution in Cali, Colombia. Eligible patients were adults diagnosed with ATL and HTLV-1 seropositivity, receiving treatment between 2011 and January 2022. Demographic, clinical, and treatment-related variables were collected and analyzed using descriptive and survival analyses. Results: Thirty-three patients diagnosed with ATL between 2011, and January 2022 were identified and included in the study. Most patients were female (52%) with a median age of 54 years. Acute presentation was the most common (64%), and most patients were identified at Ann Arbor stage 4. Treatment mainly consisted of various chemotherapy protocols, with cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (CHOP)-like regimens being the most frequently used. However, the overall response rate to chemotherapy was low, and most patients experienced complications and toxicities associated with treatment. Conclusion: This study provides insights into the clinical course and management of ATL in a Colombian population. The findings highlight the predominance of acute presentations, advanced disease stages at diagnosis, and challenges in achieving a complete response with conventional chemotherapy. Further research is needed to improve treatment strategies, identify prognostic markers, and develop more effective therapies for ATL patients in Colombia. |
| format | Article |
| id | doaj-art-12c8180ab3d743e58f49caaa6046c9dd |
| institution | Kabale University |
| issn | 2040-6215 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Hematology |
| spelling | doaj-art-12c8180ab3d743e58f49caaa6046c9dd2025-02-05T13:03:25ZengSAGE PublishingTherapeutic Advances in Hematology2040-62152025-02-011610.1177/20406207251316178Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American centerDanielle Floyd-AristizábalCristian Alonso Barreiro GarcíaOriana Arias-ValderramaCatalina Proaño MillánNhora María Silva PerezJoaquín Donaldo Rosales MartinezElizabeth Arrieta LópezBackground: Adult T-cell leukemia/lymphoma (ATL) is a neoplasm with a high prevalence in certain regions such as southwestern Japan, the Caribbean, sub-Saharan Africa, South America, and Australia. In Colombia, the seroprevalence of human T-cell lymphotropic virus type 1 (HTLV-1) has been reported in specific populations, but there is limited information about the clinical course and management of ATL in the country. Objectives: To describe the clinical characteristics, treatment patterns, and outcomes of patients diagnosed with HTLV-1-positive ATL in a high-complexity healthcare institution in Colombia and compare these findings with reports from other geographic regions. Design: Observational retrospective cohort study conducted in a single high-complexity healthcare institution in Cali, Colombia, including patients diagnosed between 2011 and January 2022. Methods: This study presents an observational retrospective cohort of patients diagnosed with HTLV-1-positive ATL and managed at a high-complexity institution in Cali, Colombia. Eligible patients were adults diagnosed with ATL and HTLV-1 seropositivity, receiving treatment between 2011 and January 2022. Demographic, clinical, and treatment-related variables were collected and analyzed using descriptive and survival analyses. Results: Thirty-three patients diagnosed with ATL between 2011, and January 2022 were identified and included in the study. Most patients were female (52%) with a median age of 54 years. Acute presentation was the most common (64%), and most patients were identified at Ann Arbor stage 4. Treatment mainly consisted of various chemotherapy protocols, with cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (CHOP)-like regimens being the most frequently used. However, the overall response rate to chemotherapy was low, and most patients experienced complications and toxicities associated with treatment. Conclusion: This study provides insights into the clinical course and management of ATL in a Colombian population. The findings highlight the predominance of acute presentations, advanced disease stages at diagnosis, and challenges in achieving a complete response with conventional chemotherapy. Further research is needed to improve treatment strategies, identify prognostic markers, and develop more effective therapies for ATL patients in Colombia.https://doi.org/10.1177/20406207251316178 |
| spellingShingle | Danielle Floyd-Aristizábal Cristian Alonso Barreiro García Oriana Arias-Valderrama Catalina Proaño Millán Nhora María Silva Perez Joaquín Donaldo Rosales Martinez Elizabeth Arrieta López Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center Therapeutic Advances in Hematology |
| title | Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center |
| title_full | Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center |
| title_fullStr | Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center |
| title_full_unstemmed | Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center |
| title_short | Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center |
| title_sort | experience in the management of patients with htlv 1 positive adult t cell leukemia lymphoma in a latin american center |
| url | https://doi.org/10.1177/20406207251316178 |
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