Primary Angiosarcoma of the Spleen: An Oncological Enigma
Introduction. Primary splenic angiosarcoma is an extremely unusual neoplasm originating from sinusoidal vascular endothelium. Surgical extirpation is the mainstay of treatment of this highly malignant disease. Case Presentation. An 82-year-old woman was admitted with left pleural effusion and a palp...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/193036 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562097988304896 |
|---|---|
| author | Myoteri Despoina Dellaportas Dionysios Ayiomamitis Georgios Strigklis Konstantinos Kouroumpas Efstratios Zizi-Sermpetzoglou Adamantia |
| author_facet | Myoteri Despoina Dellaportas Dionysios Ayiomamitis Georgios Strigklis Konstantinos Kouroumpas Efstratios Zizi-Sermpetzoglou Adamantia |
| author_sort | Myoteri Despoina |
| collection | DOAJ |
| description | Introduction. Primary splenic angiosarcoma is an extremely unusual neoplasm originating from sinusoidal vascular endothelium. Surgical extirpation is the mainstay of treatment of this highly malignant disease. Case Presentation. An 82-year-old woman was admitted with left pleural effusion and a palpable left upper quadrant abdominal mass, secondary to splenomegaly by two large splenic tumors. Classic open splenectomy was performed and angiosarcoma of the spleen was the final histopathological diagnosis, which was primary since no other disease site was revealed. Discussion. The incidence of the disease is 0.14–0.23 cases per million, with slight male predominance. Etiology is not established and clinical presentation may confuse even experienced physicians. Imaging modalities cannot differentiate the lesion from other vascular splenic neoplasms and the correct diagnosis is mainly set after histopathological examination of the resected spleen. As with other sarcomas, surgery is the only curative approach, while chemo- and radiotherapy have poor results. Prognosis remains dismal. |
| format | Article |
| id | doaj-art-1296fb7043944f1582dda870dedeaa25 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-1296fb7043944f1582dda870dedeaa252025-02-03T01:23:22ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/193036193036Primary Angiosarcoma of the Spleen: An Oncological EnigmaMyoteri Despoina0Dellaportas Dionysios1Ayiomamitis Georgios2Strigklis Konstantinos3Kouroumpas Efstratios4Zizi-Sermpetzoglou Adamantia5Department of Pathology, Tzaneio General Hospital, 185 36 Piraeus, Greece2nd Department of Surgery, Aretaieion Hospital, 115 28 Athens, Greece2nd Department of Surgery, Tzaneio General Hospital, 185 36 Piraeus, Greece2nd Department of Surgery, Tzaneio General Hospital, 185 36 Piraeus, Greece2nd Department of Surgery, Tzaneio General Hospital, 185 36 Piraeus, GreeceDepartment of Pathology, Tzaneio General Hospital, 185 36 Piraeus, GreeceIntroduction. Primary splenic angiosarcoma is an extremely unusual neoplasm originating from sinusoidal vascular endothelium. Surgical extirpation is the mainstay of treatment of this highly malignant disease. Case Presentation. An 82-year-old woman was admitted with left pleural effusion and a palpable left upper quadrant abdominal mass, secondary to splenomegaly by two large splenic tumors. Classic open splenectomy was performed and angiosarcoma of the spleen was the final histopathological diagnosis, which was primary since no other disease site was revealed. Discussion. The incidence of the disease is 0.14–0.23 cases per million, with slight male predominance. Etiology is not established and clinical presentation may confuse even experienced physicians. Imaging modalities cannot differentiate the lesion from other vascular splenic neoplasms and the correct diagnosis is mainly set after histopathological examination of the resected spleen. As with other sarcomas, surgery is the only curative approach, while chemo- and radiotherapy have poor results. Prognosis remains dismal.http://dx.doi.org/10.1155/2014/193036 |
| spellingShingle | Myoteri Despoina Dellaportas Dionysios Ayiomamitis Georgios Strigklis Konstantinos Kouroumpas Efstratios Zizi-Sermpetzoglou Adamantia Primary Angiosarcoma of the Spleen: An Oncological Enigma Case Reports in Oncological Medicine |
| title | Primary Angiosarcoma of the Spleen: An Oncological Enigma |
| title_full | Primary Angiosarcoma of the Spleen: An Oncological Enigma |
| title_fullStr | Primary Angiosarcoma of the Spleen: An Oncological Enigma |
| title_full_unstemmed | Primary Angiosarcoma of the Spleen: An Oncological Enigma |
| title_short | Primary Angiosarcoma of the Spleen: An Oncological Enigma |
| title_sort | primary angiosarcoma of the spleen an oncological enigma |
| url | http://dx.doi.org/10.1155/2014/193036 |
| work_keys_str_mv | AT myoteridespoina primaryangiosarcomaofthespleenanoncologicalenigma AT dellaportasdionysios primaryangiosarcomaofthespleenanoncologicalenigma AT ayiomamitisgeorgios primaryangiosarcomaofthespleenanoncologicalenigma AT strigkliskonstantinos primaryangiosarcomaofthespleenanoncologicalenigma AT kouroumpasefstratios primaryangiosarcomaofthespleenanoncologicalenigma AT zizisermpetzoglouadamantia primaryangiosarcomaofthespleenanoncologicalenigma |