Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review
ABSTRACT Radiofrequency ablation (RFA) is a safe and effective treatment for patients experiencing ventricular and atrial tachyarrhythmias. While complications after RFA are generally rare, the occurrence of coronary artery (CA) injury, albeit infrequent, can have significant clinical implications....
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Annals of Noninvasive Electrocardiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/anec.70021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583763351044096 |
|---|---|
| author | Syed Ali Raza Abidi Afreen Quadri Muhammad Umer Riaz Gondal Fatima Hayat Shafia Naeem Fawad Talat Amin Mehmoodi Jahanzeb Malik |
| author_facet | Syed Ali Raza Abidi Afreen Quadri Muhammad Umer Riaz Gondal Fatima Hayat Shafia Naeem Fawad Talat Amin Mehmoodi Jahanzeb Malik |
| author_sort | Syed Ali Raza Abidi |
| collection | DOAJ |
| description | ABSTRACT Radiofrequency ablation (RFA) is a safe and effective treatment for patients experiencing ventricular and atrial tachyarrhythmias. While complications after RFA are generally rare, the occurrence of coronary artery (CA) injury, albeit infrequent, can have significant clinical implications. Given the proximity of CAs to common ablation sites, understanding the interplay between RFA and CA perfusion pathophysiology is paramount. Although previous studies have discussed the presentation and outcomes of CA injury post‐ablation, a comprehensive review consolidating the mechanisms of CA injury following RFA remains absent in the cardiology literature. In this review, we conducted an extensive literature search spanning the past three decades to explore the link between the biophysics of RFA and CA perfusion pathophysiology, focusing on injury mechanisms. We delve into RFA lesion pathology, elucidate the mechanisms of CA injury resulting from RFA, and examine factors influencing lesion formation, such as convective cooling and the “shadow effect.” Furthermore, we outline methods to mitigate CA injury post‐RFA and propose novel research avenues to optimize lesion formation and ensure the safety of arrhythmia treatments, particularly in cases where tissue ablation is performed close to CAs. |
| format | Article |
| id | doaj-art-1289d906318d4c38934aa8ee8d661373 |
| institution | Kabale University |
| issn | 1082-720X 1542-474X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj-art-1289d906318d4c38934aa8ee8d6613732025-01-28T05:38:41ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2025-01-01301n/an/a10.1111/anec.70021Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive ReviewSyed Ali Raza Abidi0Afreen Quadri1Muhammad Umer Riaz Gondal2Fatima Hayat3Shafia Naeem4Fawad Talat5Amin Mehmoodi6Jahanzeb Malik7Department of Medicine Allama Iqbal Teaching Hospital DG Khan PakistanDepartment of Medicine Dr. VRK Womens Medical College Aziznagar IndiaDepartment of Medicine Reading Hospital Philadelphia USADepartment of Medicine Army Medical College Rawalpindi PakistanDepartment of Medicine University of Health Sciences Lahore PakistanDepartment of Medicine King Edward Medical University Lahore PakistanDepartment of Medicine Ibn e Seena Hospital Kabul AfghanistanCardiovascular Analytics Group Islamabad PakistanABSTRACT Radiofrequency ablation (RFA) is a safe and effective treatment for patients experiencing ventricular and atrial tachyarrhythmias. While complications after RFA are generally rare, the occurrence of coronary artery (CA) injury, albeit infrequent, can have significant clinical implications. Given the proximity of CAs to common ablation sites, understanding the interplay between RFA and CA perfusion pathophysiology is paramount. Although previous studies have discussed the presentation and outcomes of CA injury post‐ablation, a comprehensive review consolidating the mechanisms of CA injury following RFA remains absent in the cardiology literature. In this review, we conducted an extensive literature search spanning the past three decades to explore the link between the biophysics of RFA and CA perfusion pathophysiology, focusing on injury mechanisms. We delve into RFA lesion pathology, elucidate the mechanisms of CA injury resulting from RFA, and examine factors influencing lesion formation, such as convective cooling and the “shadow effect.” Furthermore, we outline methods to mitigate CA injury post‐RFA and propose novel research avenues to optimize lesion formation and ensure the safety of arrhythmia treatments, particularly in cases where tissue ablation is performed close to CAs.https://doi.org/10.1111/anec.70021arrhythmia treatmentscoronary artery injurylesion formationpathophysiologyradiofrequency ablation |
| spellingShingle | Syed Ali Raza Abidi Afreen Quadri Muhammad Umer Riaz Gondal Fatima Hayat Shafia Naeem Fawad Talat Amin Mehmoodi Jahanzeb Malik Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review Annals of Noninvasive Electrocardiology arrhythmia treatments coronary artery injury lesion formation pathophysiology radiofrequency ablation |
| title | Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review |
| title_full | Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review |
| title_fullStr | Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review |
| title_full_unstemmed | Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review |
| title_short | Pathophysiological Effects on Coronary Arteries Following Radiofrequency Ablation: A Comprehensive Review |
| title_sort | pathophysiological effects on coronary arteries following radiofrequency ablation a comprehensive review |
| topic | arrhythmia treatments coronary artery injury lesion formation pathophysiology radiofrequency ablation |
| url | https://doi.org/10.1111/anec.70021 |
| work_keys_str_mv | AT syedalirazaabidi pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT afreenquadri pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT muhammadumerriazgondal pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT fatimahayat pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT shafianaeem pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT fawadtalat pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT aminmehmoodi pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview AT jahanzebmalik pathophysiologicaleffectsoncoronaryarteriesfollowingradiofrequencyablationacomprehensivereview |