Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes
Purpose. We examined the association of CKD defined by serum creatinine, serum cystatin C, and albuminuria with moderate diabetic retinopathy (DR). Methods. We examined 1,119 Indian adults with diabetes, aged 40–80 years, who participated in the Singapore Indian Eye Study (2007–2009), a population-b...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/404280 |
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| author | Chee Wai Wong Boon Wee Teo Ecosse Lamoureux Mohammad Kamran Ikram Jie Jin Wang E. Shyong Tai Sunil Sethi Tien Yin Wong Charumathi Sabanayagam |
| author_facet | Chee Wai Wong Boon Wee Teo Ecosse Lamoureux Mohammad Kamran Ikram Jie Jin Wang E. Shyong Tai Sunil Sethi Tien Yin Wong Charumathi Sabanayagam |
| author_sort | Chee Wai Wong |
| collection | DOAJ |
| description | Purpose. We examined the association of CKD defined by serum creatinine, serum cystatin C, and albuminuria with moderate diabetic retinopathy (DR). Methods. We examined 1,119 Indian adults with diabetes, aged 40–80 years, who participated in the Singapore Indian Eye Study (2007–2009), a population-based cross-sectional study. The associations of CKD defined by each of the three markers alone and in combination with moderate DR were examined using logistic regression models adjusted for potential confounding factors including duration of diabetes, smoking, body mass index, systolic blood pressure, and HbA1c. Results. The prevalence of moderate DR was significantly higher among those with CKD defined by triple markers (41.1%) compared to CKD defined separately by creatinine (26.6%), cystatin C (20.9%), and albuminuria (23.4%). People with CKD defined by triple markers had a fourteenfold higher odds of moderate DR (OR (95% CI) = 13.63 (6.08–30.54)) compared to those without CKD by any marker. Nearly half (48.7%) of participants with cystatin C ≥ 1.12 mg/L have moderate DR. Conclusions. CKD defined by a triple marker panel was strongly associated with moderate DR in this Asian population with diabetes. |
| format | Article |
| id | doaj-art-1287263feb0e4dfda2d0de1d5a64c2e7 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1287263feb0e4dfda2d0de1d5a64c2e72025-02-03T06:13:12ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/404280404280Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with DiabetesChee Wai Wong0Boon Wee Teo1Ecosse Lamoureux2Mohammad Kamran Ikram3Jie Jin Wang4E. Shyong Tai5Sunil Sethi6Tien Yin Wong7Charumathi Sabanayagam8Singapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, 169856, SingaporeDepartment of Medicine, Singapore National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, 119074, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, 169856, SingaporeWestmead Millennium Institute for Medical Research, C24 Westmead Hospital, University of Sydney, Sydney, NSW 2006, AustraliaDepartment of Medicine, Singapore National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, 119074, SingaporeDepartment of Pathology, Singapore National University Hospital, National University of Singapore, 5 Lower Kent Ridge Road, 119074, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, The Academia, 20 College Road, Discovery Tower Level 6, 169856, SingaporePurpose. We examined the association of CKD defined by serum creatinine, serum cystatin C, and albuminuria with moderate diabetic retinopathy (DR). Methods. We examined 1,119 Indian adults with diabetes, aged 40–80 years, who participated in the Singapore Indian Eye Study (2007–2009), a population-based cross-sectional study. The associations of CKD defined by each of the three markers alone and in combination with moderate DR were examined using logistic regression models adjusted for potential confounding factors including duration of diabetes, smoking, body mass index, systolic blood pressure, and HbA1c. Results. The prevalence of moderate DR was significantly higher among those with CKD defined by triple markers (41.1%) compared to CKD defined separately by creatinine (26.6%), cystatin C (20.9%), and albuminuria (23.4%). People with CKD defined by triple markers had a fourteenfold higher odds of moderate DR (OR (95% CI) = 13.63 (6.08–30.54)) compared to those without CKD by any marker. Nearly half (48.7%) of participants with cystatin C ≥ 1.12 mg/L have moderate DR. Conclusions. CKD defined by a triple marker panel was strongly associated with moderate DR in this Asian population with diabetes.http://dx.doi.org/10.1155/2015/404280 |
| spellingShingle | Chee Wai Wong Boon Wee Teo Ecosse Lamoureux Mohammad Kamran Ikram Jie Jin Wang E. Shyong Tai Sunil Sethi Tien Yin Wong Charumathi Sabanayagam Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes Journal of Diabetes Research |
| title | Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes |
| title_full | Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes |
| title_fullStr | Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes |
| title_full_unstemmed | Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes |
| title_short | Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes |
| title_sort | serum cystatin c markers of chronic kidney disease and retinopathy in persons with diabetes |
| url | http://dx.doi.org/10.1155/2015/404280 |
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