From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota
The growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse and overuse have led to the eme...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/93 |
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| author | Hamed Tahmasebi Neda Arjmand Marzieh Monemi Ali Babaeizad Farnaz Alibabaei Negar Alibabaei Aisa Bahar Valentyn Oksenych Majid Eslami |
| author_facet | Hamed Tahmasebi Neda Arjmand Marzieh Monemi Ali Babaeizad Farnaz Alibabaei Negar Alibabaei Aisa Bahar Valentyn Oksenych Majid Eslami |
| author_sort | Hamed Tahmasebi |
| collection | DOAJ |
| description | The growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse and overuse have led to the emergence of resistant bacterial strains. Key resistance mechanisms include genetic mutations, horizontal gene transfer, and biofilm formation, with the human microbiota acting as a reservoir for antibiotic resistance genes (ARGs). Industrialization and environmental factors have exacerbated this issue, contributing to a rise in infections with multidrug-resistant (MDR) bacteria, such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and carbapenem-resistant <i>Enterobacteriaceae</i>. These resistant pathogens compromise the effectiveness of essential treatments like surgical prophylaxis and chemotherapy, increase healthcare costs, and prolong hospital stays. This crisis highlights the need for a global One-Health approach, particularly in regions with weak regulatory frameworks. Innovative strategies, including next-generation sequencing (NGS) technologies, offer promising avenues for mitigating resistance. Addressing this challenge requires coordinated efforts, encompassing research, policymaking, public education, and antibiotic stewardship, to safeguard current antibiotics and foster the development of new therapeutic solutions. An integrated, multidimensional strategy is essential to tackle this escalating problem and ensure the sustainability of effective antimicrobial treatments. |
| format | Article |
| id | doaj-art-126aac81a69448d18d625badde507ca7 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-126aac81a69448d18d625badde507ca72025-01-24T13:25:09ZengMDPI AGBiomolecules2218-273X2025-01-011519310.3390/biom15010093From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human MicrobiotaHamed Tahmasebi0Neda Arjmand1Marzieh Monemi2Ali Babaeizad3Farnaz Alibabaei4Negar Alibabaei5Aisa Bahar6Valentyn Oksenych7Majid Eslami8School of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, IranDepartment of Obstetrics and Gynecology, Tehran Medical University, Tehran 14167-53955, IranDepartment of Basic Science, Faculty of Pharmacy and Pharmaceutical Science, Tehran Medical Science, Islamic Azad University, Tehran 19395-1495, IranStudent Research Committee, Semnan University of Medical Sciences, Semnan 35147-99442, IranStudent Research Committee, Semnan University of Medical Sciences, Semnan 35147-99442, IranStudent Research Committee, Mazandaran University of Medical Sciences, Sari 48157-33971, IranDepartment of Biochemistry, Semnan University of Medical Sciences, Semnan 35147-99442, IranFaculty of Medicine, University of Bergen, 5020 Bergen, NorwayCancer Research Center, Semnan University of Medical Sciences, Semnan 35147-99442, IranThe growing prevalence of antibiotic-resistant bacteria within the human microbiome has become a pressing global health crisis. While antibiotics have revolutionized medicine by significantly reducing mortality and enabling advanced medical interventions, their misuse and overuse have led to the emergence of resistant bacterial strains. Key resistance mechanisms include genetic mutations, horizontal gene transfer, and biofilm formation, with the human microbiota acting as a reservoir for antibiotic resistance genes (ARGs). Industrialization and environmental factors have exacerbated this issue, contributing to a rise in infections with multidrug-resistant (MDR) bacteria, such as methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and carbapenem-resistant <i>Enterobacteriaceae</i>. These resistant pathogens compromise the effectiveness of essential treatments like surgical prophylaxis and chemotherapy, increase healthcare costs, and prolong hospital stays. This crisis highlights the need for a global One-Health approach, particularly in regions with weak regulatory frameworks. Innovative strategies, including next-generation sequencing (NGS) technologies, offer promising avenues for mitigating resistance. Addressing this challenge requires coordinated efforts, encompassing research, policymaking, public education, and antibiotic stewardship, to safeguard current antibiotics and foster the development of new therapeutic solutions. An integrated, multidimensional strategy is essential to tackle this escalating problem and ensure the sustainability of effective antimicrobial treatments.https://www.mdpi.com/2218-273X/15/1/93antibiotic-resistantcrisisevolutionhospital-acquired infectionsmicrobiota |
| spellingShingle | Hamed Tahmasebi Neda Arjmand Marzieh Monemi Ali Babaeizad Farnaz Alibabaei Negar Alibabaei Aisa Bahar Valentyn Oksenych Majid Eslami From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota Biomolecules antibiotic-resistant crisis evolution hospital-acquired infections microbiota |
| title | From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota |
| title_full | From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota |
| title_fullStr | From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota |
| title_full_unstemmed | From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota |
| title_short | From Cure to Crisis: Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota |
| title_sort | from cure to crisis understanding the evolution of antibiotic resistant bacteria in human microbiota |
| topic | antibiotic-resistant crisis evolution hospital-acquired infections microbiota |
| url | https://www.mdpi.com/2218-273X/15/1/93 |
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