Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique
Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation. The main goal of this experimental work was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stabili...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Chemical Engineering |
| Online Access: | http://dx.doi.org/10.1155/2011/132435 |
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| _version_ | 1832555024980377600 |
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| author | Marina Gallarate Luigi Battaglia E. Peira Michele Trotta |
| author_facet | Marina Gallarate Luigi Battaglia E. Peira Michele Trotta |
| author_sort | Marina Gallarate |
| collection | DOAJ |
| description | Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation. The main goal of this experimental work was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide-containing formulations. Insulin and leuprolide, chosen as model peptide drugs, were encapsulated within nanoparticles after hydrophobic ion pairing with anionic surfactants. Peptide integrity was maintained after encapsulation, and nanoparticles can act in vitro as a sustained release system for peptide. |
| format | Article |
| id | doaj-art-12612a92fb57490e8de5705e45f3e4b2 |
| institution | Kabale University |
| issn | 1687-806X 1687-8078 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Chemical Engineering |
| spelling | doaj-art-12612a92fb57490e8de5705e45f3e4b22025-02-03T05:49:45ZengWileyInternational Journal of Chemical Engineering1687-806X1687-80782011-01-01201110.1155/2011/132435132435Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation TechniqueMarina Gallarate0Luigi Battaglia1E. Peira2Michele Trotta3Dipartimento di Scienza e Tecnologia del Farmaco, via P. Giuria 9, 10125 Torino, ItalyDipartimento di Scienza e Tecnologia del Farmaco, via P. Giuria 9, 10125 Torino, ItalyDipartimento di Scienza e Tecnologia del Farmaco, via P. Giuria 9, 10125 Torino, ItalyDipartimento di Scienza e Tecnologia del Farmaco, via P. Giuria 9, 10125 Torino, ItalyStearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation. The main goal of this experimental work was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide-containing formulations. Insulin and leuprolide, chosen as model peptide drugs, were encapsulated within nanoparticles after hydrophobic ion pairing with anionic surfactants. Peptide integrity was maintained after encapsulation, and nanoparticles can act in vitro as a sustained release system for peptide.http://dx.doi.org/10.1155/2011/132435 |
| spellingShingle | Marina Gallarate Luigi Battaglia E. Peira Michele Trotta Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique International Journal of Chemical Engineering |
| title | Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique |
| title_full | Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique |
| title_fullStr | Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique |
| title_full_unstemmed | Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique |
| title_short | Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique |
| title_sort | peptide loaded solid lipid nanoparticles prepared through coacervation technique |
| url | http://dx.doi.org/10.1155/2011/132435 |
| work_keys_str_mv | AT marinagallarate peptideloadedsolidlipidnanoparticlespreparedthroughcoacervationtechnique AT luigibattaglia peptideloadedsolidlipidnanoparticlespreparedthroughcoacervationtechnique AT epeira peptideloadedsolidlipidnanoparticlespreparedthroughcoacervationtechnique AT micheletrotta peptideloadedsolidlipidnanoparticlespreparedthroughcoacervationtechnique |