Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients
Background. Severe pneumonia (SP) has been widely accepted as a major cause for acute respiratory distress syndrome (ARDS), and the development of ARDS is significantly associated with increased mortality. This study aimed to identify potential predictors for ARDS development in patients with SP. Me...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2019/2476845 |
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| _version_ | 1832567776557924352 |
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| author | Jun Ying Danfei Zhou Tongjie Gu Jianda Huang |
| author_facet | Jun Ying Danfei Zhou Tongjie Gu Jianda Huang |
| author_sort | Jun Ying |
| collection | DOAJ |
| description | Background. Severe pneumonia (SP) has been widely accepted as a major cause for acute respiratory distress syndrome (ARDS), and the development of ARDS is significantly associated with increased mortality. This study aimed to identify potential predictors for ARDS development in patients with SP. Methods. Eligible SP patients at admission from January 2013 to June 2017 were prospectively enrolled, and ARDS development within hospital stay was identified. Risk factors for ARDS development in SP patients were analyzed by univariate and multivariate logistic regression analysis. The receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC) was performed for the predictive value of endocan for ARDS development. Results. A total of 145 SP patients were eventually enrolled into the final analysis, of which 37 developed ARDS during the hospital stay. Our final multivariate logistic regression analysis suggested plasma endocan expression as the only independent risk factor for ARDS development in SP patients (OR: 1.57, 95% CI: 1.14–2.25, P=0.021). ROC curve analysis of plasma endocan resulted in an AUC of 0.754, 95% CI of 0.642–0.866, a cutoff value of 11.6 ng/mL, a sensitivity of 78.7%, and a specificity of 70.3%, respectively (P<0.01). Conclusions. Endocan expression at ICU admission is a reliable predictive factor in predicting ARDS in patients with SP. |
| format | Article |
| id | doaj-art-1260f9e87f20491da50b8f9717217dc4 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-1260f9e87f20491da50b8f9717217dc42025-02-03T01:00:28ZengWileyCanadian Respiratory Journal1198-22411916-72452019-01-01201910.1155/2019/24768452476845Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia PatientsJun Ying0Danfei Zhou1Tongjie Gu2Jianda Huang3Department of Respiratory, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41, Xibei Street, Ningbo 315000, Zhejiang, ChinaDepartment of Respiratory, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41, Xibei Street, Ningbo 315000, Zhejiang, ChinaDepartment of Respiratory, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41, Xibei Street, Ningbo 315000, Zhejiang, ChinaDepartment of Respiratory, Hwa Mei Hospital, University of Chinese Academy of Sciences, No. 41, Xibei Street, Ningbo 315000, Zhejiang, ChinaBackground. Severe pneumonia (SP) has been widely accepted as a major cause for acute respiratory distress syndrome (ARDS), and the development of ARDS is significantly associated with increased mortality. This study aimed to identify potential predictors for ARDS development in patients with SP. Methods. Eligible SP patients at admission from January 2013 to June 2017 were prospectively enrolled, and ARDS development within hospital stay was identified. Risk factors for ARDS development in SP patients were analyzed by univariate and multivariate logistic regression analysis. The receiver operating characteristic (ROC) curve analysis with the area under the curve (AUC) was performed for the predictive value of endocan for ARDS development. Results. A total of 145 SP patients were eventually enrolled into the final analysis, of which 37 developed ARDS during the hospital stay. Our final multivariate logistic regression analysis suggested plasma endocan expression as the only independent risk factor for ARDS development in SP patients (OR: 1.57, 95% CI: 1.14–2.25, P=0.021). ROC curve analysis of plasma endocan resulted in an AUC of 0.754, 95% CI of 0.642–0.866, a cutoff value of 11.6 ng/mL, a sensitivity of 78.7%, and a specificity of 70.3%, respectively (P<0.01). Conclusions. Endocan expression at ICU admission is a reliable predictive factor in predicting ARDS in patients with SP.http://dx.doi.org/10.1155/2019/2476845 |
| spellingShingle | Jun Ying Danfei Zhou Tongjie Gu Jianda Huang Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients Canadian Respiratory Journal |
| title | Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients |
| title_full | Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients |
| title_fullStr | Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients |
| title_full_unstemmed | Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients |
| title_short | Endocan, a Risk Factor for Developing Acute Respiratory Distress Syndrome among Severe Pneumonia Patients |
| title_sort | endocan a risk factor for developing acute respiratory distress syndrome among severe pneumonia patients |
| url | http://dx.doi.org/10.1155/2019/2476845 |
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