Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis
Background. Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children. The objective of this study was to explore potential changes in levels of serum tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) associated with pediatric MPP. Metho...
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Wiley
2018-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2018/8354892 |
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| author | Ying Wang Yongsheng Zhang Wenting Lu Liying Wang |
| author_facet | Ying Wang Yongsheng Zhang Wenting Lu Liying Wang |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Background. Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children. The objective of this study was to explore potential changes in levels of serum tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) associated with pediatric MPP. Methods. This protocol has been registered (PROSPERO 2017: CRD42017077979). A literature search was performed in October 2017 using PubMed, Embase, the Cochrane Library, and other Chinese medical databases to identify studies. The meta-analysis was performed using Review Manager 5.3 software. Random-effect models were used to estimate mean differences (MDs) and 95% confidence intervals (CIs) of cytokine levels. Results. Twelve studies were included in the meta-analysis, encompassing 2,422 children with MPP and 454 healthy control children. Serum TNF-α levels were significantly higher in children with MPP compared with healthy children (MD = 22.5, 95% CI = 13.78–31.22, P<0.00001), and there was significant heterogeneity across studies (I2 = 100%, P<0.00001). Subgroup analyses showed no evidence for a difference in serum TNF-α levels between children with refractory and nonrefractory MPP. Serum IFN-γ levels did not significantly differ in children with MPP compared with healthy children (MD = 4.83, 95% CI = −3.27–12.93, P=0.24). Conclusions. Our meta-analysis showed that serum TNF-α and IFN-γ levels were significantly elevated and unchanged, respectively, in pediatric MPP. Because infection by different pathogens has variable effects on serum TNF-α and IFN-γ levels, the finding could be helpful in developing novel diagnostic methods. |
| format | Article |
| id | doaj-art-125dfac721144d9297c8e3bd1a948492 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-125dfac721144d9297c8e3bd1a9484922025-02-03T01:26:38ZengWileyCanadian Respiratory Journal1198-22411916-72452018-01-01201810.1155/2018/83548928354892Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-AnalysisYing Wang0Yongsheng Zhang1Wenting Lu2Liying Wang3Institute of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, ChinaCentre for Reproductive Medicine and Center for Prenatal Diagnosis, The First Hospital of Jilin University, Changchun, Jilin 130021, ChinaDepartment of Molecular Biology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin 130021, ChinaInstitute of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130021, ChinaBackground. Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children. The objective of this study was to explore potential changes in levels of serum tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) associated with pediatric MPP. Methods. This protocol has been registered (PROSPERO 2017: CRD42017077979). A literature search was performed in October 2017 using PubMed, Embase, the Cochrane Library, and other Chinese medical databases to identify studies. The meta-analysis was performed using Review Manager 5.3 software. Random-effect models were used to estimate mean differences (MDs) and 95% confidence intervals (CIs) of cytokine levels. Results. Twelve studies were included in the meta-analysis, encompassing 2,422 children with MPP and 454 healthy control children. Serum TNF-α levels were significantly higher in children with MPP compared with healthy children (MD = 22.5, 95% CI = 13.78–31.22, P<0.00001), and there was significant heterogeneity across studies (I2 = 100%, P<0.00001). Subgroup analyses showed no evidence for a difference in serum TNF-α levels between children with refractory and nonrefractory MPP. Serum IFN-γ levels did not significantly differ in children with MPP compared with healthy children (MD = 4.83, 95% CI = −3.27–12.93, P=0.24). Conclusions. Our meta-analysis showed that serum TNF-α and IFN-γ levels were significantly elevated and unchanged, respectively, in pediatric MPP. Because infection by different pathogens has variable effects on serum TNF-α and IFN-γ levels, the finding could be helpful in developing novel diagnostic methods.http://dx.doi.org/10.1155/2018/8354892 |
| spellingShingle | Ying Wang Yongsheng Zhang Wenting Lu Liying Wang Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis Canadian Respiratory Journal |
| title | Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis |
| title_full | Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis |
| title_fullStr | Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis |
| title_short | Serum Tumor Necrosis Factor-α and Interferon-γ Levels in Pediatric Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis |
| title_sort | serum tumor necrosis factor α and interferon γ levels in pediatric mycoplasma pneumoniae pneumonia a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2018/8354892 |
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