Design, synthesis, SAR and ADMET analyses of the novel class of synthetic 7-amino[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate derivatives with vasorelaxant activity

Design, synthesis, SAR and ADMET analyses of the novel class of synthetic 7-amino[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate derivatives with vasorelaxant activity

A twenty six 7-amino[1,2,5]oxadiazolo[3,4-b]pyridine-6-carboxylate (7-aminofurazano[3,4-b]pyridine-6-carboxylate) derivatives have been synthesized and characterized by IR, 1H NMR, 13C NMR spectroscopy, elemental analysis and LC-MS. The potential vasodilator activity of the synthesized compounds was...

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Bibliographic Details
Main Authors: Anatolii Varenyk, Roman Vydzhak, Svitlana Panchishin, Irina Ivanova, Victor Zhirnov, Volodymyr Brovarets
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Results in Chemistry
Subjects:
Furazano[3, 4-b]pyridine
[1, 2, 5]Oxadiazolo[3, 4-b]pyridine
Nickel complexes of 1, 3-dicarbonyl compounds
Vasorelaxant activity
SAR analysis
ADMET analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625000141
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