IgG4-Related Disease Presenting as Isolated Scleritis
A rare case of IgG4-related disease (IgG4-RD) manifesting as nodular scleritis is presented in a 20-year-old female. Patient complained of left eye pain and redness for one week. Ocular examination together with ancillary testing led to the diagnosis of nodular scleritis. Since the patient did not s...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/4876587 |
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| _version_ | 1832561891471261696 |
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| author | Eran Berkowitz Ella Arnon Alona Yaakobi Yuval Cohen Beatrice Tiosano |
| author_facet | Eran Berkowitz Ella Arnon Alona Yaakobi Yuval Cohen Beatrice Tiosano |
| author_sort | Eran Berkowitz |
| collection | DOAJ |
| description | A rare case of IgG4-related disease (IgG4-RD) manifesting as nodular scleritis is presented in a 20-year-old female. Patient complained of left eye pain and redness for one week. Ocular examination together with ancillary testing led to the diagnosis of nodular scleritis. Since the patient did not show apparent improvement after one week of systemic steroidal treatment, she underwent a biopsy of the affected area revealing histopathological characteristics of IgG4-RD. Long-term treatment with corticosteroids and a steroid-sparing agent (methotrexate) led to significant improvement in signs and symptoms. This case highlights the significance of IgG4-RD in the differential diagnosis of scleritis and raises the question as to whether various organs affected by IgG4-RD may have different underlying pathophysiological mechanisms in which pathogenic T cells play a role. |
| format | Article |
| id | doaj-art-1227235a3e8b49adb850a8708ff6c842 |
| institution | Kabale University |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-1227235a3e8b49adb850a8708ff6c8422025-02-03T01:23:48ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302017-01-01201710.1155/2017/48765874876587IgG4-Related Disease Presenting as Isolated ScleritisEran Berkowitz0Ella Arnon1Alona Yaakobi2Yuval Cohen3Beatrice Tiosano4Department of Ophthalmology, Hillel Yaffe Medical Center Affiliated with The Bruce Rappaport School of Medicine, The Technion, Haifa, IsraelDepartment of Ophthalmology, Hillel Yaffe Medical Center Affiliated with The Bruce Rappaport School of Medicine, The Technion, Haifa, IsraelDepartment of Ophthalmology, Hillel Yaffe Medical Center Affiliated with The Bruce Rappaport School of Medicine, The Technion, Haifa, IsraelDepartment of Ophthalmology, Hillel Yaffe Medical Center Affiliated with The Bruce Rappaport School of Medicine, The Technion, Haifa, IsraelDepartment of Ophthalmology, Hillel Yaffe Medical Center Affiliated with The Bruce Rappaport School of Medicine, The Technion, Haifa, IsraelA rare case of IgG4-related disease (IgG4-RD) manifesting as nodular scleritis is presented in a 20-year-old female. Patient complained of left eye pain and redness for one week. Ocular examination together with ancillary testing led to the diagnosis of nodular scleritis. Since the patient did not show apparent improvement after one week of systemic steroidal treatment, she underwent a biopsy of the affected area revealing histopathological characteristics of IgG4-RD. Long-term treatment with corticosteroids and a steroid-sparing agent (methotrexate) led to significant improvement in signs and symptoms. This case highlights the significance of IgG4-RD in the differential diagnosis of scleritis and raises the question as to whether various organs affected by IgG4-RD may have different underlying pathophysiological mechanisms in which pathogenic T cells play a role.http://dx.doi.org/10.1155/2017/4876587 |
| spellingShingle | Eran Berkowitz Ella Arnon Alona Yaakobi Yuval Cohen Beatrice Tiosano IgG4-Related Disease Presenting as Isolated Scleritis Case Reports in Ophthalmological Medicine |
| title | IgG4-Related Disease Presenting as Isolated Scleritis |
| title_full | IgG4-Related Disease Presenting as Isolated Scleritis |
| title_fullStr | IgG4-Related Disease Presenting as Isolated Scleritis |
| title_full_unstemmed | IgG4-Related Disease Presenting as Isolated Scleritis |
| title_short | IgG4-Related Disease Presenting as Isolated Scleritis |
| title_sort | igg4 related disease presenting as isolated scleritis |
| url | http://dx.doi.org/10.1155/2017/4876587 |
| work_keys_str_mv | AT eranberkowitz igg4relateddiseasepresentingasisolatedscleritis AT ellaarnon igg4relateddiseasepresentingasisolatedscleritis AT alonayaakobi igg4relateddiseasepresentingasisolatedscleritis AT yuvalcohen igg4relateddiseasepresentingasisolatedscleritis AT beatricetiosano igg4relateddiseasepresentingasisolatedscleritis |