Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays

A mathematical model for growth of tumors with two discrete delays is studied. The delays, respectively, represent the time taken for cells to undergo mitosis and the time taken for the cell to modify the rate of cell loss due to apoptosis and kill of cells by the inhibitor. We show the influence of...

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Main Authors: Bao Shi, Fangwei Zhang, Shihe Xu
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Abstract and Applied Analysis
Online Access:http://dx.doi.org/10.1155/2011/980686
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author Bao Shi
Fangwei Zhang
Shihe Xu
author_facet Bao Shi
Fangwei Zhang
Shihe Xu
author_sort Bao Shi
collection DOAJ
description A mathematical model for growth of tumors with two discrete delays is studied. The delays, respectively, represent the time taken for cells to undergo mitosis and the time taken for the cell to modify the rate of cell loss due to apoptosis and kill of cells by the inhibitor. We show the influence of time delays on the Hopf bifurcation when one of delays is used as a bifurcation parameter.
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publishDate 2011-01-01
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series Abstract and Applied Analysis
spelling doaj-art-121d70a44b3c485d9385a657745d88372025-02-03T01:10:46ZengWileyAbstract and Applied Analysis1085-33751687-04092011-01-01201110.1155/2011/980686980686Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time DelaysBao Shi0Fangwei Zhang1Shihe Xu2Institute of Systems Science and Mathematics, Naval Aeronautical and Astronautical University, Yantai, Shandong 264001, ChinaInstitute of Systems Science and Mathematics, Naval Aeronautical and Astronautical University, Yantai, Shandong 264001, ChinaDepartment of Mathematics, Zhaoqing University, Zhaoqing, Guangdong 526061, ChinaA mathematical model for growth of tumors with two discrete delays is studied. The delays, respectively, represent the time taken for cells to undergo mitosis and the time taken for the cell to modify the rate of cell loss due to apoptosis and kill of cells by the inhibitor. We show the influence of time delays on the Hopf bifurcation when one of delays is used as a bifurcation parameter.http://dx.doi.org/10.1155/2011/980686
spellingShingle Bao Shi
Fangwei Zhang
Shihe Xu
Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays
Abstract and Applied Analysis
title Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays
title_full Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays
title_fullStr Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays
title_full_unstemmed Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays
title_short Hopf Bifurcation of a Mathematical Model for Growth of Tumors with an Action of Inhibitor and Two Time Delays
title_sort hopf bifurcation of a mathematical model for growth of tumors with an action of inhibitor and two time delays
url http://dx.doi.org/10.1155/2011/980686
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