Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses
Abstract Air pollution, especially particulate matter (PM), is one of the most common risk factors for global burden of disease. However, its effect on the risk of digestive diseases is unclear. Herein, we attempt to explore this issue by reviewing the existing evidence from published meta-analyses....
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-024-21257-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594318433452032 |
|---|---|
| author | Haonan Zhao Xiaojie Zheng Guo Lin Xiaomin Wang Huiyuan Lu Pengpeng Xie Siqi Jia Yiyang Shang Yan Wang Pengchu Bai Xuan Zhang Ning Tang Xingshun Qi |
| author_facet | Haonan Zhao Xiaojie Zheng Guo Lin Xiaomin Wang Huiyuan Lu Pengpeng Xie Siqi Jia Yiyang Shang Yan Wang Pengchu Bai Xuan Zhang Ning Tang Xingshun Qi |
| author_sort | Haonan Zhao |
| collection | DOAJ |
| description | Abstract Air pollution, especially particulate matter (PM), is one of the most common risk factors for global burden of disease. However, its effect on the risk of digestive diseases is unclear. Herein, we attempt to explore this issue by reviewing the existing evidence from published meta-analyses. We conducted a systematic literature search to identify all relevant meta-analyses regarding the association of air pollution with digestive diseases, and summarize their major findings. We assessed the methodological quality and evidence quality of the included meta-analyses using the AMSTAR-2 and GRADE tools, respectively, and the overlap of primary studies was assessed by the GROOVE tool. Nine meta-analyses were included in our analysis, containing 43 primary studies with high overlap. In the included meta-analyses, the methodological quality was from critically low to moderate, and the evidence quality was from very low to moderate. The exposure was primarily PM2.5. Seven, four, and one meta-analysis investigated the effect of air pollution on liver diseases, gastrointestinal diseases, and pancreatic diseases, respectively. PM2.5 exposure was significantly associated with liver dysfunction, chronic liver diseases, liver cancer, and colorectal cancer, but not oesophagus cancer, gastric cancer, or pancreatic cancer. Based on very low to moderate quality evidence from meta-analyses, PM2.5 exposure may contribute to the development of some digestive diseases, especially liver diseases. |
| format | Article |
| id | doaj-art-121264af7f0a4c45b530d25b0cd61c14 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-121264af7f0a4c45b530d25b0cd61c142025-01-19T12:41:32ZengBMCBMC Public Health1471-24582025-01-0125111710.1186/s12889-024-21257-3Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analysesHaonan Zhao0Xiaojie Zheng1Guo Lin2Xiaomin Wang3Huiyuan Lu4Pengpeng Xie5Siqi Jia6Yiyang Shang7Yan Wang8Pengchu Bai9Xuan Zhang10Ning Tang11Xingshun Qi12Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Graduate School of Medical Sciences, Kanazawa UniversityGraduate School of Medical Sciences, Kanazawa UniversityNational Institute of Occupational Safety and HealthInstitute of Nature and Environmental Technology, Kanazawa UniversityDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of Shenyang Pharmaceutical University)Abstract Air pollution, especially particulate matter (PM), is one of the most common risk factors for global burden of disease. However, its effect on the risk of digestive diseases is unclear. Herein, we attempt to explore this issue by reviewing the existing evidence from published meta-analyses. We conducted a systematic literature search to identify all relevant meta-analyses regarding the association of air pollution with digestive diseases, and summarize their major findings. We assessed the methodological quality and evidence quality of the included meta-analyses using the AMSTAR-2 and GRADE tools, respectively, and the overlap of primary studies was assessed by the GROOVE tool. Nine meta-analyses were included in our analysis, containing 43 primary studies with high overlap. In the included meta-analyses, the methodological quality was from critically low to moderate, and the evidence quality was from very low to moderate. The exposure was primarily PM2.5. Seven, four, and one meta-analysis investigated the effect of air pollution on liver diseases, gastrointestinal diseases, and pancreatic diseases, respectively. PM2.5 exposure was significantly associated with liver dysfunction, chronic liver diseases, liver cancer, and colorectal cancer, but not oesophagus cancer, gastric cancer, or pancreatic cancer. Based on very low to moderate quality evidence from meta-analyses, PM2.5 exposure may contribute to the development of some digestive diseases, especially liver diseases.https://doi.org/10.1186/s12889-024-21257-3Umbrella reviewParticulate matterLiver diseasesGastrointestinal diseasesPancreatic diseases |
| spellingShingle | Haonan Zhao Xiaojie Zheng Guo Lin Xiaomin Wang Huiyuan Lu Pengpeng Xie Siqi Jia Yiyang Shang Yan Wang Pengchu Bai Xuan Zhang Ning Tang Xingshun Qi Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses BMC Public Health Umbrella review Particulate matter Liver diseases Gastrointestinal diseases Pancreatic diseases |
| title | Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses |
| title_full | Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses |
| title_fullStr | Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses |
| title_full_unstemmed | Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses |
| title_short | Effects of air pollution on the development and progression of digestive diseases: an umbrella review of systematic reviews and meta-analyses |
| title_sort | effects of air pollution on the development and progression of digestive diseases an umbrella review of systematic reviews and meta analyses |
| topic | Umbrella review Particulate matter Liver diseases Gastrointestinal diseases Pancreatic diseases |
| url | https://doi.org/10.1186/s12889-024-21257-3 |
| work_keys_str_mv | AT haonanzhao effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT xiaojiezheng effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT guolin effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT xiaominwang effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT huiyuanlu effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT pengpengxie effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT siqijia effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT yiyangshang effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT yanwang effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT pengchubai effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT xuanzhang effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT ningtang effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses AT xingshunqi effectsofairpollutiononthedevelopmentandprogressionofdigestivediseasesanumbrellareviewofsystematicreviewsandmetaanalyses |