Temporal dynamics of neutrophil functions in multiple sclerosis
Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory ne...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996124003462 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850110869282750464 |
|---|---|
| author | Shishi Shen Shilin Wu Yuge Wang Li Xiao Xiaobo Sun Wenxuan Sun Yipeng Zhao Rui Li Jiaqi Zhang Zhanhang Wang Shaoli Zhou Shixiong Huang Yanyu Chang Yaqing Shu Chen Chen Zhengqi Lu Wei Cai Wei Qiu |
| author_facet | Shishi Shen Shilin Wu Yuge Wang Li Xiao Xiaobo Sun Wenxuan Sun Yipeng Zhao Rui Li Jiaqi Zhang Zhanhang Wang Shaoli Zhou Shixiong Huang Yanyu Chang Yaqing Shu Chen Chen Zhengqi Lu Wei Cai Wei Qiu |
| author_sort | Shishi Shen |
| collection | DOAJ |
| description | Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory neutrophil counts and disease activity and severity in treatment-naïve MS patients. In experimental autoimmune encephalomyelitis (EAE), we documented the recruitment of neutrophils to spinal cord during the preclinical phase, with these cells contributing to the disruption of the blood-spinal cord barrier (BSCB) during the onset of the disease. Furthermore, during the peak phase, infiltrated neutrophils promoted demyelination through formation of neutrophil extracellular traps (NETs), cytokine secretion and antigen presentation. Notably, the inhibition of neutrophil infiltration using a CXCR2 inhibitor effectively mitigated white matter damage and physical disability, underscoring their potential as therapeutic targets. In conclusion, neutrophils represent promising candidates for both disease treatment and prognosis evaluation in MS. By elucidating their temporal roles and mechanisms of action, we can potentially harness their modulation to improve patient outcomes and disease management. |
| format | Article |
| id | doaj-art-120b1e9c7aae4fd79c1af8edf3d3dca7 |
| institution | OA Journals |
| issn | 1095-953X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-120b1e9c7aae4fd79c1af8edf3d3dca72025-08-20T02:37:45ZengElsevierNeurobiology of Disease1095-953X2024-12-0120310674410.1016/j.nbd.2024.106744Temporal dynamics of neutrophil functions in multiple sclerosisShishi Shen0Shilin Wu1Yuge Wang2Li Xiao3Xiaobo Sun4Wenxuan Sun5Yipeng Zhao6Rui Li7Jiaqi Zhang8Zhanhang Wang9Shaoli Zhou10Shixiong Huang11Yanyu Chang12Yaqing Shu13Chen Chen14Zhengqi Lu15Wei Cai16Wei Qiu17Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou, Guangdong 510000, ChinaDepartment of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Hainan Provincial People's Hospital, Haikou, Hainan 570100, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Department of Neurology, The First People's Hospital of Kashi, Kashi, Xinjiang 844000, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, ChinaDepartment of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Corresponding author at: Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Corresponding author at: Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China; Department of Neurology, The First People's Hospital of Kashi, Kashi, Xinjiang 844000, China; Corresponding author at: Department of Neurology, Mental and Neurological Disease Research Center, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.Early neuroinflammatory injury plays a crucial role in initiating and progressing multiple sclerosis (MS). Neutrophils are forerunners to neural lesions in MS, yet the temporal alterations of their functions in MS remains unclear. This study demonstrated a positive correlation between circulatory neutrophil counts and disease activity and severity in treatment-naïve MS patients. In experimental autoimmune encephalomyelitis (EAE), we documented the recruitment of neutrophils to spinal cord during the preclinical phase, with these cells contributing to the disruption of the blood-spinal cord barrier (BSCB) during the onset of the disease. Furthermore, during the peak phase, infiltrated neutrophils promoted demyelination through formation of neutrophil extracellular traps (NETs), cytokine secretion and antigen presentation. Notably, the inhibition of neutrophil infiltration using a CXCR2 inhibitor effectively mitigated white matter damage and physical disability, underscoring their potential as therapeutic targets. In conclusion, neutrophils represent promising candidates for both disease treatment and prognosis evaluation in MS. By elucidating their temporal roles and mechanisms of action, we can potentially harness their modulation to improve patient outcomes and disease management.http://www.sciencedirect.com/science/article/pii/S0969996124003462Neutrophil heterogeneityEarly lesionDemyelinationMultiple sclerosisBlood brain barrierAntigen presentation |
| spellingShingle | Shishi Shen Shilin Wu Yuge Wang Li Xiao Xiaobo Sun Wenxuan Sun Yipeng Zhao Rui Li Jiaqi Zhang Zhanhang Wang Shaoli Zhou Shixiong Huang Yanyu Chang Yaqing Shu Chen Chen Zhengqi Lu Wei Cai Wei Qiu Temporal dynamics of neutrophil functions in multiple sclerosis Neurobiology of Disease Neutrophil heterogeneity Early lesion Demyelination Multiple sclerosis Blood brain barrier Antigen presentation |
| title | Temporal dynamics of neutrophil functions in multiple sclerosis |
| title_full | Temporal dynamics of neutrophil functions in multiple sclerosis |
| title_fullStr | Temporal dynamics of neutrophil functions in multiple sclerosis |
| title_full_unstemmed | Temporal dynamics of neutrophil functions in multiple sclerosis |
| title_short | Temporal dynamics of neutrophil functions in multiple sclerosis |
| title_sort | temporal dynamics of neutrophil functions in multiple sclerosis |
| topic | Neutrophil heterogeneity Early lesion Demyelination Multiple sclerosis Blood brain barrier Antigen presentation |
| url | http://www.sciencedirect.com/science/article/pii/S0969996124003462 |
| work_keys_str_mv | AT shishishen temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT shilinwu temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT yugewang temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT lixiao temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT xiaobosun temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT wenxuansun temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT yipengzhao temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT ruili temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT jiaqizhang temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT zhanhangwang temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT shaolizhou temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT shixionghuang temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT yanyuchang temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT yaqingshu temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT chenchen temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT zhengqilu temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT weicai temporaldynamicsofneutrophilfunctionsinmultiplesclerosis AT weiqiu temporaldynamicsofneutrophilfunctionsinmultiplesclerosis |