Low-grade inflammation in prognosis in patients undergoing coronary artery bypass grafting: The importance of neutrophil-to-lymphocyte ratio and growth differentiation factor 15
Background — Predicting major adverse cardiovascular events (MACE) after coronary interventions is an urgent and important mission. Subclinical inflammation markers are increasingly investigated for this purpose. Objective: To determine the role of neutrophil-to-lymphocyte ratio (NLR) and growth dif...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Limited liability company «Science and Innovations» (Saratov)
2025-03-01
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| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | https://romj.org/node/597 |
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| Summary: | Background — Predicting major adverse cardiovascular events (MACE) after coronary interventions is an urgent and important mission. Subclinical inflammation markers are increasingly investigated for this purpose. Objective: To determine the role of neutrophil-to-lymphocyte ratio (NLR) and growth differentiation factor 15 (GDF-15) in predicting MACE in patients after coronary artery bypass grafting (CABG).
Methods — This prospective observational study included 80 patients with coronary artery disease who underwent CABG and were followed for at least a year. In prospective follow-up, the composite endpoint (MACE) constituted 27.5% (22 events).
Results — GDF-15 and NLR values were similar in the groups with and without MACE. ROC analysis showed low AUC for NLR (AUC=0.566, p=0.363) and GDF-15 (AUC=0.621, p=0.096). The value of the GDF-15×NLR product was calculated. The median was 3,108.05 (2,069; 4,145) for patients without MACE and 4,108.8 (2,779.4; 5,890.5) for patients with MACE (p=0.010). This association remained after adjustment for gender, age, diabetes mellitus, and left ventricular ejection fraction.
Conclusion — The product, NLR×GDF-15, is associated with adverse cardiovascular events in patients after CABG. |
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| ISSN: | 2304-3415 |