Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways
African swine fever virus (ASFV), a highly lethal pathogen, poses a catastrophic threat to global pork production. While some commercial vaccines exist, their availability remains regional limitations. This review investigates the mechanistic interplay between ASFV and antigen-presenting cells (APCs...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2541711 |
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| _version_ | 1849234288635019264 |
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| author | Penghao Lv Zhichao Wang Haowei Chen Yanru Chen Hanlin Liao Kaiyue Wei Shuying Lv Min Cui |
| author_facet | Penghao Lv Zhichao Wang Haowei Chen Yanru Chen Hanlin Liao Kaiyue Wei Shuying Lv Min Cui |
| author_sort | Penghao Lv |
| collection | DOAJ |
| description | African swine fever virus (ASFV), a highly lethal pathogen, poses a catastrophic threat to global pork production. While some commercial vaccines exist, their availability remains regional limitations. This review investigates the mechanistic interplay between ASFV and antigen-presenting cells (APCs), with a particular focus on viral evasion strategies that disrupt antigen presentation pathways. Although current understanding of ASFV immunology has largely focused on monocyte/macrophage infection, we provide a systematic analysis of ASFV-mediated immunosuppression across various APCs, including dendritic cells (DCs), B lymphocytes, and γδ T cells, and compare these mechanisms with those employed by other viral pathogens. Key objectives include: (1) synthesizing ASFV-induced dysregulation of antigen presentation, (2) identifying critical gaps in APC-virus interactions, and (3) guiding vaccine development priorities. By highlighting understudied DC-ASFV interplay and potential molecular targets, this work provides a strategic framework for next-generation vaccine design based on host-pathogen conflict at the antigen presentation interface. |
| format | Article |
| id | doaj-art-11d3d5201d9c426e8d3fd053873aedb0 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-11d3d5201d9c426e8d3fd053873aedb02025-08-20T04:03:12ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2541711Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathwaysPenghao Lv0Zhichao Wang1Haowei Chen2Yanru Chen3Hanlin Liao4Kaiyue Wei5Shuying Lv6Min Cui7State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaDepartment of English Teaching and Research Section, Dongying Vocational College, Dongying, ChinaState Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, ChinaAfrican swine fever virus (ASFV), a highly lethal pathogen, poses a catastrophic threat to global pork production. While some commercial vaccines exist, their availability remains regional limitations. This review investigates the mechanistic interplay between ASFV and antigen-presenting cells (APCs), with a particular focus on viral evasion strategies that disrupt antigen presentation pathways. Although current understanding of ASFV immunology has largely focused on monocyte/macrophage infection, we provide a systematic analysis of ASFV-mediated immunosuppression across various APCs, including dendritic cells (DCs), B lymphocytes, and γδ T cells, and compare these mechanisms with those employed by other viral pathogens. Key objectives include: (1) synthesizing ASFV-induced dysregulation of antigen presentation, (2) identifying critical gaps in APC-virus interactions, and (3) guiding vaccine development priorities. By highlighting understudied DC-ASFV interplay and potential molecular targets, this work provides a strategic framework for next-generation vaccine design based on host-pathogen conflict at the antigen presentation interface.https://www.tandfonline.com/doi/10.1080/21505594.2025.2541711African swine feverAfrican swine fever virusantigen presentationadaptive immunityvaccines |
| spellingShingle | Penghao Lv Zhichao Wang Haowei Chen Yanru Chen Hanlin Liao Kaiyue Wei Shuying Lv Min Cui Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways Virulence African swine fever African swine fever virus antigen presentation adaptive immunity vaccines |
| title | Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways |
| title_full | Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways |
| title_fullStr | Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways |
| title_full_unstemmed | Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways |
| title_short | Immunoevasion strategies for African swine fever virus: Modulation of antigen presentation pathways |
| title_sort | immunoevasion strategies for african swine fever virus modulation of antigen presentation pathways |
| topic | African swine fever African swine fever virus antigen presentation adaptive immunity vaccines |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2541711 |
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