Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia
Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called “niches.” The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differentiation ability of HSC are regulated by two major elements: en...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/375857 |
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| author | Bella S. Guerrouahen Ibrahim Al-Hijji Arash Rafii Tabrizi |
| author_facet | Bella S. Guerrouahen Ibrahim Al-Hijji Arash Rafii Tabrizi |
| author_sort | Bella S. Guerrouahen |
| collection | DOAJ |
| description | Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called “niches.” The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differentiation ability of HSC are regulated by two major elements: endosteal and vascular regulatory elements. The osteoblastic niche localized at the inner surface of the bone cavity might serve as a reservoir for long-term HSC storage in a quiescent state. Whereas the vascular niche, which consists of sinusoidal endothelial cell lining blood vessel, provides an environment for short-term HSC proliferation and differentiation. Both niches act together to maintain hematopoietic homeostasis. In this paper, we provide some principles applying to the hematopoietic niches, which will be useful in the study and understanding of other stem cell niches. We will discuss altered microenvironment signaling leading to myeloid lineage disease. And finally, we will review some data on the development of acute myeloid leukemia from a subpopulation called leukemia-initiating cells (LIC), and we will discuss on the emerging evidences supporting the influence of the microenvironment on chemotherapy resistance. |
| format | Article |
| id | doaj-art-11cf5dedf90346139e0294d9e3aafd6c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-11cf5dedf90346139e0294d9e3aafd6c2025-02-03T06:01:37ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/375857375857Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of LeukemiaBella S. Guerrouahen0Ibrahim Al-Hijji1Arash Rafii Tabrizi2Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10022, USAHamad Medical Corporation, Doha, QatarDepartment of Genetic Medicine, Weill Cornell Medical College, New York, NY 10022, USAStem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called “niches.” The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differentiation ability of HSC are regulated by two major elements: endosteal and vascular regulatory elements. The osteoblastic niche localized at the inner surface of the bone cavity might serve as a reservoir for long-term HSC storage in a quiescent state. Whereas the vascular niche, which consists of sinusoidal endothelial cell lining blood vessel, provides an environment for short-term HSC proliferation and differentiation. Both niches act together to maintain hematopoietic homeostasis. In this paper, we provide some principles applying to the hematopoietic niches, which will be useful in the study and understanding of other stem cell niches. We will discuss altered microenvironment signaling leading to myeloid lineage disease. And finally, we will review some data on the development of acute myeloid leukemia from a subpopulation called leukemia-initiating cells (LIC), and we will discuss on the emerging evidences supporting the influence of the microenvironment on chemotherapy resistance.http://dx.doi.org/10.4061/2011/375857 |
| spellingShingle | Bella S. Guerrouahen Ibrahim Al-Hijji Arash Rafii Tabrizi Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia Stem Cells International |
| title | Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia |
| title_full | Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia |
| title_fullStr | Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia |
| title_full_unstemmed | Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia |
| title_short | Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia |
| title_sort | osteoblastic and vascular endothelial niches their control on normal hematopoietic stem cells and their consequences on the development of leukemia |
| url | http://dx.doi.org/10.4061/2011/375857 |
| work_keys_str_mv | AT bellasguerrouahen osteoblasticandvascularendothelialnichestheircontrolonnormalhematopoieticstemcellsandtheirconsequencesonthedevelopmentofleukemia AT ibrahimalhijji osteoblasticandvascularendothelialnichestheircontrolonnormalhematopoieticstemcellsandtheirconsequencesonthedevelopmentofleukemia AT arashrafiitabrizi osteoblasticandvascularendothelialnichestheircontrolonnormalhematopoieticstemcellsandtheirconsequencesonthedevelopmentofleukemia |