Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ
We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furtherm...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2017/3728485 |
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| author | Marlon Osorio Jorge Velásquez-Cock Luz Marina Restrepo Robín Zuluaga Piedad Gañán Orlando J. Rojas Isabel Ortiz-Trujillo Cristina Castro |
| author_facet | Marlon Osorio Jorge Velásquez-Cock Luz Marina Restrepo Robín Zuluaga Piedad Gañán Orlando J. Rojas Isabel Ortiz-Trujillo Cristina Castro |
| author_sort | Marlon Osorio |
| collection | DOAJ |
| description | We investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment. |
| format | Article |
| id | doaj-art-11cedb2cdb9540babd601d1c0bac59aa |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-11cedb2cdb9540babd601d1c0bac59aa2025-02-03T05:53:46ZengWileyInternational Journal of Polymer Science1687-94221687-94302017-01-01201710.1155/2017/37284853728485Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In SituMarlon Osorio0Jorge Velásquez-Cock1Luz Marina Restrepo2Robín Zuluaga3Piedad Gañán4Orlando J. Rojas5Isabel Ortiz-Trujillo6Cristina Castro7Facultad de Ingeniería Química, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, ColombiaFacultad de Ingeniería Química, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, ColombiaSchool of Health Sciences, Universidad de Antioquia, Calle 51D 62-29, Medellín, ColombiaFacultad de Ingeniería Agroindustrial, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, ColombiaFacultad de Ingeniería Química, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, ColombiaBiobased Colloids and Materials Group (BiCMat), Department of Forest Product Technology, Aalto University, School of Chemical Technology, Espoo, FinlandFacultad de Medicina, Universidad Pontificia Bolivariana, Calle 78B No. 72A-109, Medellín, ColombiaFacultad de Ingeniería Textil, Universidad Pontificia Bolivariana, Circular 1, No. 70-01, Medellín, ColombiaWe investigated wound dressing composites comprising fibrils of bacterial cellulose (BC) grown by fermentation in the presence of polyvinyl alcohol (PVA) followed by physical crosslinking. The reference biointerface, neat BC, favoured adhesion of fibroblasts owing to size exclusion effects. Furthermore, it resisted migration across the biomaterial. Such effects were minimized in the case of PVA/BC membranes. Therefore, the latter are suggested in cases where cell adhesion is to be avoided, for instance, in the design of interactive wound dressings with facile exudate control. The bioactivity and other properties of the membranes were related to their morphology and structure and considered those of collagen fibres. Bioactive materials were produced by simple 3D templating of BC during growth and proposed for burn and skin ulcer treatment.http://dx.doi.org/10.1155/2017/3728485 |
| spellingShingle | Marlon Osorio Jorge Velásquez-Cock Luz Marina Restrepo Robín Zuluaga Piedad Gañán Orlando J. Rojas Isabel Ortiz-Trujillo Cristina Castro Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ International Journal of Polymer Science |
| title | Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ |
| title_full | Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ |
| title_fullStr | Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ |
| title_full_unstemmed | Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ |
| title_short | Bioactive 3D-Shaped Wound Dressings Synthesized from Bacterial Cellulose: Effect on Cell Adhesion of Polyvinyl Alcohol Integrated In Situ |
| title_sort | bioactive 3d shaped wound dressings synthesized from bacterial cellulose effect on cell adhesion of polyvinyl alcohol integrated in situ |
| url | http://dx.doi.org/10.1155/2017/3728485 |
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