Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism
As global aging intensifies, the incidence of age-related bone metabolic disorders, such as osteoporosis, continues to climb. Seeking safe and effective therapeutic interventions is of utmost importance. The modulation of bone metabolism by the gut microbiota and their metabolites has emerged as a f...
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China Food Publishing Company
2025-01-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-2-029.pdf |
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| author | ZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan |
| author_facet | ZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan |
| author_sort | ZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan |
| collection | DOAJ |
| description | As global aging intensifies, the incidence of age-related bone metabolic disorders, such as osteoporosis, continues to climb. Seeking safe and effective therapeutic interventions is of utmost importance. The modulation of bone metabolism by the gut microbiota and their metabolites has emerged as a focal area of research. Short-chain fatty acids (SCFAs), including acetic, propionic, and butyric acids, exert regulatory effects on bone formation and resorption through the gut-bone axis. Furthermore, SCFAs play positive roles in maintaining bone homeostasis and contribute to the alleviation of inflammatory bone loss. This review synthesizes the current knowledge about the mechanism by which SCFAs regulate bone metabolic homeostasis via endocrine pathways, immune modulation, and enhanced nutrient absorption, hoping to provide a scientific foundation for the prevention and treatment of metabolic bone diseases in the elderly. |
| format | Article |
| id | doaj-art-11caabb2c88d468faef5094e8ecc2ca2 |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-11caabb2c88d468faef5094e8ecc2ca22025-02-05T09:08:22ZengChina Food Publishing CompanyShipin Kexue1002-66302025-01-0146226026710.7506/spkx1002-6630-20240610-060Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone MetabolismZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan0(1. Key Laboratory of Quality &Safety Control for Dairy Products of China Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China; 2. Laboratory of Quality &Safety Risk Assessment for Dairy Products of China Ministry of Agriculture and Rural Affairs (Beijing), Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China)As global aging intensifies, the incidence of age-related bone metabolic disorders, such as osteoporosis, continues to climb. Seeking safe and effective therapeutic interventions is of utmost importance. The modulation of bone metabolism by the gut microbiota and their metabolites has emerged as a focal area of research. Short-chain fatty acids (SCFAs), including acetic, propionic, and butyric acids, exert regulatory effects on bone formation and resorption through the gut-bone axis. Furthermore, SCFAs play positive roles in maintaining bone homeostasis and contribute to the alleviation of inflammatory bone loss. This review synthesizes the current knowledge about the mechanism by which SCFAs regulate bone metabolic homeostasis via endocrine pathways, immune modulation, and enhanced nutrient absorption, hoping to provide a scientific foundation for the prevention and treatment of metabolic bone diseases in the elderly.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-2-029.pdfgut-bone axis; short-chain fatty acids; intestinal microbes; bone metabolism; osteoporosis |
| spellingShingle | ZHANG Xuan, YANG Xue, LI Xinke, MENG Lu, WANG Jiaqi, ZHENG Nan Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism Shipin Kexue gut-bone axis; short-chain fatty acids; intestinal microbes; bone metabolism; osteoporosis |
| title | Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism |
| title_full | Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism |
| title_fullStr | Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism |
| title_full_unstemmed | Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism |
| title_short | Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism |
| title_sort | research progress in short chain fatty acid modulation of the gut bone axis in bone metabolism |
| topic | gut-bone axis; short-chain fatty acids; intestinal microbes; bone metabolism; osteoporosis |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-2-029.pdf |
| work_keys_str_mv | AT zhangxuanyangxuelixinkemengluwangjiaqizhengnan researchprogressinshortchainfattyacidmodulationofthegutboneaxisinbonemetabolism |