Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study
Purpose. To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP. Design. This is a retrospective observational study. Methods. We collected vein blood from 101 cases of patients with nonsyndromic...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/1902915 |
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| _version_ | 1832551649862746112 |
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| author | Yijing Yang Ying Deng Ye Tian Zhen Yao Yasha Zhou Ying Wang Qinghua Peng Jun Peng |
| author_facet | Yijing Yang Ying Deng Ye Tian Zhen Yao Yasha Zhou Ying Wang Qinghua Peng Jun Peng |
| author_sort | Yijing Yang |
| collection | DOAJ |
| description | Purpose. To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP. Design. This is a retrospective observational study. Methods. We collected vein blood from 101 cases of patients with nonsyndromic RP and 120 cases of normal individuals according to a single-blind study and used routine clinical examination to detect the indicators of blood. All the subjects were mainly from the central south of China. Data were analyzed statistically between the RP group and normal control. Results. The indicator of platelet distribution width (PDW) in patients with RP was higher than that in the normal group; the indicators of red blood cell (RBCs), hemoglobin (HGB), hematocrit (HCT), basophils (BASs), platelets (PLTs), and plateletcrit (PCT) in the RP group were lower than those in the normal control. The differences were statistically very significant between the RP group and normal group (p<0.01). There were no statistical differences in the other indicators between the RP and normal group. Conclusions. The changes in RBCs and PLTs in patients with RP implied that RP induces RBC aggregation and platelet activation, leading to blood stasis which in turn initiates more apoptosis. |
| format | Article |
| id | doaj-art-11c805fad74e4c7b87e507203a537ab4 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-11c805fad74e4c7b87e507203a537ab42025-02-03T06:00:54ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/19029151902915Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective StudyYijing Yang0Ying Deng1Ye Tian2Zhen Yao3Yasha Zhou4Ying Wang5Qinghua Peng6Jun Peng7Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, ChinaHunan Provincial Hospital of Chinese Medicine, Zhuzhou 412083, Hunan Province, ChinaHunan University of Chinese Medicine, Changsha 410208, Hunan Province, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, ChinaPurpose. To investigate the characteristics of blood in nonsyndromic retinitis pigmentosa (RP) and reveal the pathogenesis of blood cells involved in blood stasis in RP. Design. This is a retrospective observational study. Methods. We collected vein blood from 101 cases of patients with nonsyndromic RP and 120 cases of normal individuals according to a single-blind study and used routine clinical examination to detect the indicators of blood. All the subjects were mainly from the central south of China. Data were analyzed statistically between the RP group and normal control. Results. The indicator of platelet distribution width (PDW) in patients with RP was higher than that in the normal group; the indicators of red blood cell (RBCs), hemoglobin (HGB), hematocrit (HCT), basophils (BASs), platelets (PLTs), and plateletcrit (PCT) in the RP group were lower than those in the normal control. The differences were statistically very significant between the RP group and normal group (p<0.01). There were no statistical differences in the other indicators between the RP and normal group. Conclusions. The changes in RBCs and PLTs in patients with RP implied that RP induces RBC aggregation and platelet activation, leading to blood stasis which in turn initiates more apoptosis.http://dx.doi.org/10.1155/2019/1902915 |
| spellingShingle | Yijing Yang Ying Deng Ye Tian Zhen Yao Yasha Zhou Ying Wang Qinghua Peng Jun Peng Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study Journal of Ophthalmology |
| title | Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study |
| title_full | Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study |
| title_fullStr | Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study |
| title_full_unstemmed | Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study |
| title_short | Investigation of Blood Characteristics in Nonsyndromic Retinitis Pigmentosa: A Retrospective Study |
| title_sort | investigation of blood characteristics in nonsyndromic retinitis pigmentosa a retrospective study |
| url | http://dx.doi.org/10.1155/2019/1902915 |
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