Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model
Katarzyna Uzdrowska,1 Narcyz Knap,1 Lucyna Konieczna,2 Anna Kamm,1 Alicja Kuban-Jankowska,1 Joanna Gierałtowska,3 Mariusz Belka,2 Magdalena Baran,3 Adrian Chlanda,3 Krystian Michał Kowiorski,3 Aleksander Żołnierski,4 Jacek Gulczynski,5 Ludwika Lipi&nacut...
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Dove Medical Press
2025-01-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/combined-graphene-oxide-with-2-methoxyestradiol-for-effective-anticanc-peer-reviewed-fulltext-article-IJN |
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| author | Uzdrowska K Knap N Konieczna L Kamm A Kuban-Jankowska A Gierałtowska J Belka M Baran M Chlanda A Kowiorski KM Żołnierski A Gulczynski J Lipińska L Bączek T Izycka-Swieszewska E Górska-Ponikowska M |
| author_facet | Uzdrowska K Knap N Konieczna L Kamm A Kuban-Jankowska A Gierałtowska J Belka M Baran M Chlanda A Kowiorski KM Żołnierski A Gulczynski J Lipińska L Bączek T Izycka-Swieszewska E Górska-Ponikowska M |
| author_sort | Uzdrowska K |
| collection | DOAJ |
| description | Katarzyna Uzdrowska,1 Narcyz Knap,1 Lucyna Konieczna,2 Anna Kamm,1 Alicja Kuban-Jankowska,1 Joanna Gierałtowska,3 Mariusz Belka,2 Magdalena Baran,3 Adrian Chlanda,3 Krystian Michał Kowiorski,3 Aleksander Żołnierski,4 Jacek Gulczynski,5 Ludwika Lipińska,3 Tomasz Bączek,2 Ewa Izycka-Swieszewska,5 Magdalena Górska-Ponikowska1 1Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland; 2Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland; 3Łukasiewicz Research Network - Institute of Microelectronics and Photonics, Warsaw, Poland; 4The Institute of Economic Sciences of the Polish Academy of Sciences, Warsaw, Poland; 5Faculty of Health Sciences with the Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Gdansk, PolandCorrespondence: Magdalena Górska-Ponikowska, Email magdalena.gorska-ponikowska@gumed.edu.plIntroduction: This article describes the invention of graphene oxide (GO) or reduced graphene oxide (rGO) functionalised with 2-methoxy estradiol. The presence of polar hydroxyl groups enables the binding of 2-ME to GO/rGO through hydrogen bonds with epoxy and hydroxyl groups located on the surface and carbonyl and carboxyl groups located at the edges of graphene flake sheets.Methods: The patented method of producing the subject of the invention and the research results regarding its anticancer effectiveness via cytotoxicity in an in vivo model (against A375 melanoma and 143B osteosarcoma cells) are described.Results: It was shown that the inhibition of PTP1B phosphotyrosine phosphatase is one of the mechanisms of action of GO functionalised with 2-ME (GO-2-ME). This is a very important result, considering the fact that 2-ME itself has no inhibitory properties against this phosphatase.Discussion: Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME. An appropriate dosage of GO-2-ME/rGO-2-ME, in which GO/rGO is a carrier of 2-methoxyestradiol (2-ME), can ensure effective penetration of the active substance through biological boundaries/membranes and controlled modification of cell signalling, ultimately leading to the selective elimination of malignant cells.Keywords: new graphene-based anticancer drugs, graphene-based oncological therapy, new anticancer treatment, biomedical innovations, drugs delivery systems |
| format | Article |
| id | doaj-art-11c6778927c5415cb14f28eda0b642c3 |
| institution | Kabale University |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-11c6778927c5415cb14f28eda0b642c32025-01-21T16:58:06ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-01-01Volume 2093395099455Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro ModelUzdrowska KKnap NKonieczna LKamm AKuban-Jankowska AGierałtowska JBelka MBaran MChlanda AKowiorski KMŻołnierski AGulczynski JLipińska LBączek TIzycka-Swieszewska EGórska-Ponikowska MKatarzyna Uzdrowska,1 Narcyz Knap,1 Lucyna Konieczna,2 Anna Kamm,1 Alicja Kuban-Jankowska,1 Joanna Gierałtowska,3 Mariusz Belka,2 Magdalena Baran,3 Adrian Chlanda,3 Krystian Michał Kowiorski,3 Aleksander Żołnierski,4 Jacek Gulczynski,5 Ludwika Lipińska,3 Tomasz Bączek,2 Ewa Izycka-Swieszewska,5 Magdalena Górska-Ponikowska1 1Department of Medical Chemistry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland; 2Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland; 3Łukasiewicz Research Network - Institute of Microelectronics and Photonics, Warsaw, Poland; 4The Institute of Economic Sciences of the Polish Academy of Sciences, Warsaw, Poland; 5Faculty of Health Sciences with the Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Gdansk, PolandCorrespondence: Magdalena Górska-Ponikowska, Email magdalena.gorska-ponikowska@gumed.edu.plIntroduction: This article describes the invention of graphene oxide (GO) or reduced graphene oxide (rGO) functionalised with 2-methoxy estradiol. The presence of polar hydroxyl groups enables the binding of 2-ME to GO/rGO through hydrogen bonds with epoxy and hydroxyl groups located on the surface and carbonyl and carboxyl groups located at the edges of graphene flake sheets.Methods: The patented method of producing the subject of the invention and the research results regarding its anticancer effectiveness via cytotoxicity in an in vivo model (against A375 melanoma and 143B osteosarcoma cells) are described.Results: It was shown that the inhibition of PTP1B phosphotyrosine phosphatase is one of the mechanisms of action of GO functionalised with 2-ME (GO-2-ME). This is a very important result, considering the fact that 2-ME itself has no inhibitory properties against this phosphatase.Discussion: Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME. An appropriate dosage of GO-2-ME/rGO-2-ME, in which GO/rGO is a carrier of 2-methoxyestradiol (2-ME), can ensure effective penetration of the active substance through biological boundaries/membranes and controlled modification of cell signalling, ultimately leading to the selective elimination of malignant cells.Keywords: new graphene-based anticancer drugs, graphene-based oncological therapy, new anticancer treatment, biomedical innovations, drugs delivery systemshttps://www.dovepress.com/combined-graphene-oxide-with-2-methoxyestradiol-for-effective-anticanc-peer-reviewed-fulltext-article-IJNnew graphene-based anticancer drugsgraphene- based oncological therapynew anticancer treatmentbiomedical innovationsdrugs delivery systems |
| spellingShingle | Uzdrowska K Knap N Konieczna L Kamm A Kuban-Jankowska A Gierałtowska J Belka M Baran M Chlanda A Kowiorski KM Żołnierski A Gulczynski J Lipińska L Bączek T Izycka-Swieszewska E Górska-Ponikowska M Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model International Journal of Nanomedicine new graphene-based anticancer drugs graphene- based oncological therapy new anticancer treatment biomedical innovations drugs delivery systems |
| title | Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model |
| title_full | Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model |
| title_fullStr | Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model |
| title_full_unstemmed | Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model |
| title_short | Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model |
| title_sort | combined graphene oxide with 2 methoxyestradiol for effective anticancer therapy in vitro model |
| topic | new graphene-based anticancer drugs graphene- based oncological therapy new anticancer treatment biomedical innovations drugs delivery systems |
| url | https://www.dovepress.com/combined-graphene-oxide-with-2-methoxyestradiol-for-effective-anticanc-peer-reviewed-fulltext-article-IJN |
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