The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde
Novel complexes were synthesized from Schiff base ligand (L) produced by reacting 3-hydrocyclo-1,3-dihydro-indole-2-one (A) with 2-pyridine carboxaldehyde in an ethanol medium. This study aims to synthesize the metal Schiff base ligands complexes of heterocyclic, which tested their biological...
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University of Baghdad
2025-01-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
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| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3612 |
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| author | safa sami Muwafaq Naser Shaalan |
| author_facet | safa sami Muwafaq Naser Shaalan |
| author_sort | safa sami Muwafaq |
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Novel complexes were synthesized from Schiff base ligand (L) produced by reacting 3-hydrocyclo-1,3-dihydro-indole-2-one (A) with 2-pyridine carboxaldehyde in an ethanol medium. This study aims to synthesize the metal Schiff base ligands complexes of heterocyclic, which tested their biological activity as antimicrobial drugs. Metal complexes comprising manganese, cobalt, nickel, copper, and zinc with Schiff base have been produced at a molar ratio of 1:1 (M: L). These complexes were identified using M.P, FT-IR, UV-Vis, Mass, 1H-NMR, and C.H.N. Chloride-containing, atomic absorption, molar conductance, and magnetic susceptibility have all been used to identify these compounds. Utilizing mass spectroscopy, the molecular ion peak was found at m/e 251.01, confirming the formula weight for L, which matches the estimated m+ value (250.26). The results show a hexadentate coordination geometry for each complex and the ligand with good yield. This study emphasizes the importance of using a metal complexation method to stabilize ligands and increase their bioactivity. The biological activities of the new compounds were valued against Gram-positive (Escherichia coli) and Gram-negative (Staphylococcus aureus). Hence, their results were good in inhibition.
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| format | Article |
| id | doaj-art-11b9345f6a634ae4af7bcf373699c69f |
| institution | Kabale University |
| issn | 1609-4042 2521-3407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Baghdad |
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| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj-art-11b9345f6a634ae4af7bcf373699c69f2025-01-22T01:21:06ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072025-01-0138110.30526/38.1.3612The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehydesafa sami Muwafaq0https://orcid.org/0009-0000-1516-7805Naser Shaalan1https://orcid.org/0000-0002-2875-5056Department of Chemistry, College of Sciences for Woman, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Sciences for Woman, University of Baghdad, Baghdad, Iraq. Novel complexes were synthesized from Schiff base ligand (L) produced by reacting 3-hydrocyclo-1,3-dihydro-indole-2-one (A) with 2-pyridine carboxaldehyde in an ethanol medium. This study aims to synthesize the metal Schiff base ligands complexes of heterocyclic, which tested their biological activity as antimicrobial drugs. Metal complexes comprising manganese, cobalt, nickel, copper, and zinc with Schiff base have been produced at a molar ratio of 1:1 (M: L). These complexes were identified using M.P, FT-IR, UV-Vis, Mass, 1H-NMR, and C.H.N. Chloride-containing, atomic absorption, molar conductance, and magnetic susceptibility have all been used to identify these compounds. Utilizing mass spectroscopy, the molecular ion peak was found at m/e 251.01, confirming the formula weight for L, which matches the estimated m+ value (250.26). The results show a hexadentate coordination geometry for each complex and the ligand with good yield. This study emphasizes the importance of using a metal complexation method to stabilize ligands and increase their bioactivity. The biological activities of the new compounds were valued against Gram-positive (Escherichia coli) and Gram-negative (Staphylococcus aureus). Hence, their results were good in inhibition. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3612Biological activitiesisatin2-pyridine carboxaldehydeSchiff base complexesmetal complex |
| spellingShingle | safa sami Muwafaq Naser Shaalan The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde Ibn Al-Haitham Journal for Pure and Applied Sciences Biological activities isatin 2-pyridine carboxaldehyde Schiff base complexes metal complex |
| title | The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde |
| title_full | The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde |
| title_fullStr | The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde |
| title_full_unstemmed | The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde |
| title_short | The Synthesis, Characterization and Biological Activity of Some Metal Ions Complexes with Schiff’s Bases Derived from Reaction of 3-Hydrazone-1,3- Dihydro-Indole-2-One with 2- Pyridine Carboxaldehyde |
| title_sort | synthesis characterization and biological activity of some metal ions complexes with schiff s bases derived from reaction of 3 hydrazone 1 3 dihydro indole 2 one with 2 pyridine carboxaldehyde |
| topic | Biological activities isatin 2-pyridine carboxaldehyde Schiff base complexes metal complex |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3612 |
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