Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]
New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (H1, C13, a...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2010/149149 |
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| author | Shadia A. Elsayed Ahmed M. El-Hendawy Sahar I. Mostafa Bertrand J. Jean-Claude Margarita Todorova Ian S. Butler |
| author_facet | Shadia A. Elsayed Ahmed M. El-Hendawy Sahar I. Mostafa Bertrand J. Jean-Claude Margarita Todorova Ian S. Butler |
| author_sort | Shadia A. Elsayed |
| collection | DOAJ |
| description | New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (H1, C13, and P31), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116). |
| format | Article |
| id | doaj-art-11b36232589d44368ae61bc93d68cddb |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-11b36232589d44368ae61bc93d68cddb2025-02-03T00:59:24ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2010-01-01201010.1155/2010/149149149149Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]Shadia A. Elsayed0Ahmed M. El-Hendawy1Sahar I. Mostafa2Bertrand J. Jean-Claude3Margarita Todorova4Ian S. Butler5Department of Chemistry, McGill University, Montreal, QC, H3A 2K6, CanadaChemistry Department, Faculty of Science, Mansoura University, Damietta 34517, EgyptChemistry Department, Faculty of Science, Mansoura University, Mansoura, EgyptDepartment of Medicine, Royal Victoria Hospital, Montreal, QC, H3A 1A1, CanadaDepartment of Medicine, Royal Victoria Hospital, Montreal, QC, H3A 1A1, CanadaDepartment of Chemistry, McGill University, Montreal, QC, H3A 2K6, CanadaNew complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (H1, C13, and P31), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).http://dx.doi.org/10.1155/2010/149149 |
| spellingShingle | Shadia A. Elsayed Ahmed M. El-Hendawy Sahar I. Mostafa Bertrand J. Jean-Claude Margarita Todorova Ian S. Butler Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] Bioinorganic Chemistry and Applications |
| title | Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] |
| title_full | Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] |
| title_fullStr | Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] |
| title_full_unstemmed | Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] |
| title_short | Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] |
| title_sort | antineoplastic activity of new transition metal complexes of 6 methylpyridine 2 carbaldehyde n 4 ethylthiosemicarbazone x ray crystal structures of vo2 mpetsc and pt mpetsc cl |
| url | http://dx.doi.org/10.1155/2010/149149 |
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