Regulation of Neutrophil Survival/Apoptosis by Mcl-1
Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammatory neutrophils and their clearance are critical con...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2011/131539 |
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| _version_ | 1832546110223155200 |
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| author | Eric Milot János G. Filep |
| author_facet | Eric Milot János G. Filep |
| author_sort | Eric Milot |
| collection | DOAJ |
| description | Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammatory neutrophils and their clearance are critical control points for termination of the inflammatory response. Evasion of neutrophil apoptosis aggravates local injury and leads to persistent tissue damage. The short-lived prosurvival Bcl-2 family protein, Mcl-1 (myeloid cell leukemia-1), is instrumental in controlling apoptosis and consequently neutrophil lifespan in response to rapidly changing environmental cues during inflammation. This paper will focus on multiple levels of control of Mcl-1 expression and function and will discuss targeting Mcl-1 as a potential therapeutic strategy to enhance the resolution of inflammation through accelerating neutrophil apoptosis. |
| format | Article |
| id | doaj-art-11a7a6fe36a0437fa5eb8f313bdd7c92 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-11a7a6fe36a0437fa5eb8f313bdd7c922025-02-03T07:23:52ZengWileyThe Scientific World Journal1537-744X2011-01-01111948196210.1100/2011/131539131539Regulation of Neutrophil Survival/Apoptosis by Mcl-1Eric Milot0János G. Filep1Department of Medicine, Research Center Maisonneuve-Rosemont Hospital, University of Montreal, 5415 Boulevard de l'Assomption, Montreal, QC, H1T 2M4, CanadaDepartment of Pathology and Cell Biology, Research Center Maisonneuve-Rosemont Hospital, University of Montreal, 5415 Boulevard de l'Assomption, Montreal, QC, H1T 2M4, CanadaNeutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammatory neutrophils and their clearance are critical control points for termination of the inflammatory response. Evasion of neutrophil apoptosis aggravates local injury and leads to persistent tissue damage. The short-lived prosurvival Bcl-2 family protein, Mcl-1 (myeloid cell leukemia-1), is instrumental in controlling apoptosis and consequently neutrophil lifespan in response to rapidly changing environmental cues during inflammation. This paper will focus on multiple levels of control of Mcl-1 expression and function and will discuss targeting Mcl-1 as a potential therapeutic strategy to enhance the resolution of inflammation through accelerating neutrophil apoptosis.http://dx.doi.org/10.1100/2011/131539 |
| spellingShingle | Eric Milot János G. Filep Regulation of Neutrophil Survival/Apoptosis by Mcl-1 The Scientific World Journal |
| title | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
| title_full | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
| title_fullStr | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
| title_full_unstemmed | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
| title_short | Regulation of Neutrophil Survival/Apoptosis by Mcl-1 |
| title_sort | regulation of neutrophil survival apoptosis by mcl 1 |
| url | http://dx.doi.org/10.1100/2011/131539 |
| work_keys_str_mv | AT ericmilot regulationofneutrophilsurvivalapoptosisbymcl1 AT janosgfilep regulationofneutrophilsurvivalapoptosisbymcl1 |