Impact of neoadjuvant systemic therapy on surgical and radiotherapy outcomes in patients with early-stage breast cancer: a cross-sectional retrospective single-center study

Impact of neoadjuvant systemic therapy on surgical and radiotherapy outcomes in patients with early-stage breast cancer: a cross-sectional retrospective single-center study

Abstract Introduction Neoadjuvant systemic therapy (NST) may cause non-concentric tumor shrinkage, complicating excision volume definition and potentially increasing radiotherapy boost volumes, affecting cosmetic outcomes. This study aims to compare excision and boost volumes in patients undergoing...

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Main Authors: Yasmin A. Civil, Katya M. Duvivier, Sanne A. L. Bartels, Susanne van der Velde, C. Willemien Menke-van der Houven van Oordt, Ellis Barbé, Suzan van der Meij, Berend J. Slotman, Desirée van den Bongard
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Breast cancer
Neoadjuvant systemic therapy
Excision volume
Boost volume
Cosmetic outcome
Quality of life
Online Access:https://doi.org/10.1186/s12885-025-14438-9
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