The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.

The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.

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Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly understood. Here, we determined the crystal structure of the lipri...

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Bibliographic Details
Main Authors: Gaowei Jin, Joaquín Campos, Yang Liu, Berta Marcó de la Cruz, Shujing Zhang, Mingfu Liang, Kaiyue Li, Xingqiao Xie, Fredrik H Sterky, Claudio Acuna, Zhiyi Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002817
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