CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway

CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway

Abstract Background Given that lymphatic metastasis represents a pivotal determinant of poor clinical outcomes in tongue squamous cell carcinoma (TSCC), this study aimed to elucidate the role of the CXCR4/CXCL12 chemokine axis in TSCC lymphatic metastasis and its clinical significance. Methods We ex...

Full description

Saved in:
Bibliographic Details
Main Authors: Huiquan Lou, Yichao Xia, Shengjie Shao, Xiang Liu, Zengzheng Li, Hongbin Yu, Yongsheng Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
CXCR4
CXCL12
Tongue squamous cell carcinoma
Lymphatic metastasis
PI3K/AKT pathway
Lymphangiogenesis
Online Access:https://doi.org/10.1186/s12967-025-06707-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-025-06707-9

Similar Items