Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation
Abstract Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced...
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12097 |
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| author | Shushu Xue Junrong Jiao Si Miao Lijun Wang Yang Liu Qingjie Zhang Qiyue Wang Yu Xi Yuanyuan Zhang |
| author_facet | Shushu Xue Junrong Jiao Si Miao Lijun Wang Yang Liu Qingjie Zhang Qiyue Wang Yu Xi Yuanyuan Zhang |
| author_sort | Shushu Xue |
| collection | DOAJ |
| description | Abstract Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced side effects. Here, the authors designed lipid‐decorated bismuth‐based nanoflowers (DP‐BNFs) as both a radiosensitiser and a photothermal therapy agent for LMBC treatment. The BNFs were prepared by oxidation of bismuth nitrate and subsequent reduction using sodium borohydride. The preparation parameters and formulation of DP‐BNFs were optimised via a single‐factor experiment, with the factors including reaction temperature, a molar ratio of reducing agents, and the types and amount of decorated lipid materials. The result indicated that the BNFs prepared at 170°C with the Bi/NaBH4 ratio of 1:0.7 exhibited the best yield and particle size around 160 nm. After being spray dried with lactose to prepare dry powder inhalation (DP‐BNF@Lat‐MPs), their effects on improving therapeutic efficiency of the radiotherapy and photothermal therapy combination were measured using the western blot assay to determine the tumour apoptosis. In a word, DP‐BNF@Lat‐MPs could be a novel inhalable integrated microsphere that provides a new possibility for thermoradiotherapy of LMBC. |
| format | Article |
| id | doaj-art-119b78baa98e47f48a04a99acf503462 |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-119b78baa98e47f48a04a99acf5034622025-02-03T01:29:36ZengWileyIET Nanobiotechnology1751-87411751-875X2022-12-0116930531510.1049/nbt2.12097Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisationShushu Xue0Junrong Jiao1Si Miao2Lijun Wang3Yang Liu4Qingjie Zhang5Qiyue Wang6Yu Xi7Yuanyuan Zhang8Department of Radiotherapy Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Radiotherapy Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Pharmaceutics State Key Laboratory of Nature Medicines China Pharmaceutical University Nanjing ChinaDepartment of Radiotherapy Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Pharmaceutics State Key Laboratory of Nature Medicines China Pharmaceutical University Nanjing ChinaDepartment of Pharmaceutics State Key Laboratory of Nature Medicines China Pharmaceutical University Nanjing ChinaSchool of Pharmaceutical Science Nanjing Tech University Nanjing ChinaDepartment of Pharmacy Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaDepartment of Pharmacy Jiangsu Cancer Hospital Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University Nanjing ChinaAbstract Lung metastatic breast cancer (LMBC) leads to a large number of deaths in women with breast cancer, and radiotherapy has been considered the common assay for tumour therapy except for surgery. However, radiotherapy still faces problems of low efficiency due to resistance and easily induced side effects. Here, the authors designed lipid‐decorated bismuth‐based nanoflowers (DP‐BNFs) as both a radiosensitiser and a photothermal therapy agent for LMBC treatment. The BNFs were prepared by oxidation of bismuth nitrate and subsequent reduction using sodium borohydride. The preparation parameters and formulation of DP‐BNFs were optimised via a single‐factor experiment, with the factors including reaction temperature, a molar ratio of reducing agents, and the types and amount of decorated lipid materials. The result indicated that the BNFs prepared at 170°C with the Bi/NaBH4 ratio of 1:0.7 exhibited the best yield and particle size around 160 nm. After being spray dried with lactose to prepare dry powder inhalation (DP‐BNF@Lat‐MPs), their effects on improving therapeutic efficiency of the radiotherapy and photothermal therapy combination were measured using the western blot assay to determine the tumour apoptosis. In a word, DP‐BNF@Lat‐MPs could be a novel inhalable integrated microsphere that provides a new possibility for thermoradiotherapy of LMBC.https://doi.org/10.1049/nbt2.12097bismuth nanoflowerdry powder inhalationlung metastatic breast canceroptimisationradiosensitiser |
| spellingShingle | Shushu Xue Junrong Jiao Si Miao Lijun Wang Yang Liu Qingjie Zhang Qiyue Wang Yu Xi Yuanyuan Zhang Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation IET Nanobiotechnology bismuth nanoflower dry powder inhalation lung metastatic breast cancer optimisation radiosensitiser |
| title | Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation |
| title_full | Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation |
| title_fullStr | Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation |
| title_full_unstemmed | Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation |
| title_short | Lipid‐coated bismuth nanoflower as the thermos‐radio sensiti for therapy of lung metastatic breast cancer: Preparation, optimisation, and characterisation |
| title_sort | lipid coated bismuth nanoflower as the thermos radio sensiti for therapy of lung metastatic breast cancer preparation optimisation and characterisation |
| topic | bismuth nanoflower dry powder inhalation lung metastatic breast cancer optimisation radiosensitiser |
| url | https://doi.org/10.1049/nbt2.12097 |
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