Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study
Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese community-...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/605280 |
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| author | Alex Gileles-Hillel María Luz Alonso-Álvarez Leila Kheirandish-Gozal Eduard Peris José Aurelio Cordero-Guevara Joaquin Terán-Santos Mónica Gonzalez Martinez María José Jurado-Luque Jaime Corral-Peñafiel Joaquin Duran-Cantolla David Gozal |
| author_facet | Alex Gileles-Hillel María Luz Alonso-Álvarez Leila Kheirandish-Gozal Eduard Peris José Aurelio Cordero-Guevara Joaquin Terán-Santos Mónica Gonzalez Martinez María José Jurado-Luque Jaime Corral-Peñafiel Joaquin Duran-Cantolla David Gozal |
| author_sort | Alex Gileles-Hillel |
| collection | DOAJ |
| description | Introduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic (PSG) variables. Methods. In this cross-sectional, prospective multicenter study, healthy obese Spanish children (ages 4–15 years) were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw. Plasma samples were assayed for multiple inflammatory markers. Results. 204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index (RDI) of 3 events/hour total sleep time (TST). BMI, gender, and age were similar in OSA and no-OSA children. Monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in OSA children, with interleukin-6 concentrations being higher in moderate-severe OSA (i.e., AHI > 5/hrTST; P<0.01), while MCP-1 levels were associated with more prolonged nocturnal hypercapnia (P<0.001). Conclusion. IL-6, MCP-1, and PAI-1 are altered in the context of OSA among community-based obese children further reinforcing the proinflammatory effects of sleep disorders such as OSA. This trial is registered with ClinicalTrials.gov NCT01322763. |
| format | Article |
| id | doaj-art-118a2d34012d416f8900148596617f96 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-118a2d34012d416f8900148596617f962025-02-03T06:10:58ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/605280605280Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS StudyAlex Gileles-Hillel0María Luz Alonso-Álvarez1Leila Kheirandish-Gozal2Eduard Peris3José Aurelio Cordero-Guevara4Joaquin Terán-Santos5Mónica Gonzalez Martinez6María José Jurado-Luque7Jaime Corral-Peñafiel8Joaquin Duran-Cantolla9David Gozal10Section of Sleep Medicine, Department of Pediatrics, Comer Children’s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USASleep Unit, Instituto Carlos III.CIBERES, SpainSection of Sleep Medicine, Department of Pediatrics, Comer Children’s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USASection of Sleep Medicine, Department of Pediatrics, Comer Children’s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USASleep Unit, Instituto Carlos III.CIBERES, SpainSleep Unit, Instituto Carlos III.CIBERES, SpainSleep Unit, Instituto Carlos III.CIBERES, SpainSleep Unit, Instituto Carlos III.CIBERES, SpainSleep Unit, Instituto Carlos III.CIBERES, SpainSleep Unit, Instituto Carlos III.CIBERES, SpainSection of Sleep Medicine, Department of Pediatrics, Comer Children’s Hospital, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USAIntroduction. Obesity and obstructive sleep apnea syndrome (OSA) are common coexisting conditions associated with a chronic low-grade inflammatory state underlying some of the cognitive, metabolic, and cardiovascular morbidities. Aim. To examine the levels of inflammatory markers in obese community-dwelling children with OSA, as compared to no-OSA, and their association with clinical and polysomnographic (PSG) variables. Methods. In this cross-sectional, prospective multicenter study, healthy obese Spanish children (ages 4–15 years) were randomly selected and underwent nocturnal PSG followed by a morning fasting blood draw. Plasma samples were assayed for multiple inflammatory markers. Results. 204 children were enrolled in the study; 75 had OSA, defined by an obstructive respiratory disturbance index (RDI) of 3 events/hour total sleep time (TST). BMI, gender, and age were similar in OSA and no-OSA children. Monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in OSA children, with interleukin-6 concentrations being higher in moderate-severe OSA (i.e., AHI > 5/hrTST; P<0.01), while MCP-1 levels were associated with more prolonged nocturnal hypercapnia (P<0.001). Conclusion. IL-6, MCP-1, and PAI-1 are altered in the context of OSA among community-based obese children further reinforcing the proinflammatory effects of sleep disorders such as OSA. This trial is registered with ClinicalTrials.gov NCT01322763.http://dx.doi.org/10.1155/2014/605280 |
| spellingShingle | Alex Gileles-Hillel María Luz Alonso-Álvarez Leila Kheirandish-Gozal Eduard Peris José Aurelio Cordero-Guevara Joaquin Terán-Santos Mónica Gonzalez Martinez María José Jurado-Luque Jaime Corral-Peñafiel Joaquin Duran-Cantolla David Gozal Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study Mediators of Inflammation |
| title | Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study |
| title_full | Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study |
| title_fullStr | Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study |
| title_full_unstemmed | Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study |
| title_short | Inflammatory Markers and Obstructive Sleep Apnea in Obese Children: The NANOS Study |
| title_sort | inflammatory markers and obstructive sleep apnea in obese children the nanos study |
| url | http://dx.doi.org/10.1155/2014/605280 |
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