Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors
Introduction. The results obtained with dynamic PET (dPET) were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST). The primary aim was to assess the association of the dPET results and gene expression data. Material and Methods. dPET was performed foll...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/721313 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565557735456768 |
|---|---|
| author | Ludwig G. Strauss Antonia Dimitrakopoulou-Strauss Dirk Koczan Leyun Pan Peter Hohenberger |
| author_facet | Ludwig G. Strauss Antonia Dimitrakopoulou-Strauss Dirk Koczan Leyun Pan Peter Hohenberger |
| author_sort | Ludwig G. Strauss |
| collection | DOAJ |
| description | Introduction. The results obtained with dynamic PET (dPET) were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST). The primary aim was to assess the association of the dPET results and gene expression data. Material and Methods. dPET was performed following the injection of F-18-fluorodeoxyglucose (FDG) in 22 patients with GIST. All patients were examined prior to surgery for staging purpose. Compartment and noncompartment models were used for the quantitative evaluation of the dPET examinations. Gene array data were based on tumor specimen obtained by surgery after the PET examinations. Results. The data analysis revealed significant correlations for the dPET parameters and the expression of zinc finger genes (znf43, znf85, znf91, znf189). Furthermore, the transport of FDG (k1) was associated with VEGF-A. The cell cycle gene cyclin-dependent kinase inhibitor 1C was correlated with the maximum tracer uptake (SUVmax) in the tumors. Conclusions. The data demonstrate a dependency of the tracer kinetics on genes associated with prognosis in GIST. Furthermore, angiogenesis and cell proliferation have an impact on the tracer uptake. |
| format | Article |
| id | doaj-art-11891cb4f53340b5b2f1f6c90bdfc081 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-11891cb4f53340b5b2f1f6c90bdfc0812025-02-03T01:07:13ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/721313721313Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal TumorsLudwig G. Strauss0Antonia Dimitrakopoulou-Strauss1Dirk Koczan2Leyun Pan3Peter Hohenberger4Medical PET Group, Biological Imaging, CCU Nuclear Medicine, German Cancer Research Center, 69120 Heidelberg, GermanyMedical PET Group, Biological Imaging, CCU Nuclear Medicine, German Cancer Research Center, 69120 Heidelberg, GermanyMolecular Immunology Group, Institute of Immunology, University of Rostock, 18055 Rostock, GermanyMedical PET Group, Biological Imaging, CCU Nuclear Medicine, German Cancer Research Center, 69120 Heidelberg, GermanyDivision of Surgical Oncology and Thoracic Surgery, Department of Surgery, Mannheim University Medical Center, University of Heidelberg, 69135 Mannheim, GermanyIntroduction. The results obtained with dynamic PET (dPET) were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST). The primary aim was to assess the association of the dPET results and gene expression data. Material and Methods. dPET was performed following the injection of F-18-fluorodeoxyglucose (FDG) in 22 patients with GIST. All patients were examined prior to surgery for staging purpose. Compartment and noncompartment models were used for the quantitative evaluation of the dPET examinations. Gene array data were based on tumor specimen obtained by surgery after the PET examinations. Results. The data analysis revealed significant correlations for the dPET parameters and the expression of zinc finger genes (znf43, znf85, znf91, znf189). Furthermore, the transport of FDG (k1) was associated with VEGF-A. The cell cycle gene cyclin-dependent kinase inhibitor 1C was correlated with the maximum tracer uptake (SUVmax) in the tumors. Conclusions. The data demonstrate a dependency of the tracer kinetics on genes associated with prognosis in GIST. Furthermore, angiogenesis and cell proliferation have an impact on the tracer uptake.http://dx.doi.org/10.1100/2012/721313 |
| spellingShingle | Ludwig G. Strauss Antonia Dimitrakopoulou-Strauss Dirk Koczan Leyun Pan Peter Hohenberger Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors The Scientific World Journal |
| title | Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors |
| title_full | Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors |
| title_fullStr | Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors |
| title_full_unstemmed | Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors |
| title_short | Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors |
| title_sort | correlation of dynamic pet and gene array data in patients with gastrointestinal stromal tumors |
| url | http://dx.doi.org/10.1100/2012/721313 |
| work_keys_str_mv | AT ludwiggstrauss correlationofdynamicpetandgenearraydatainpatientswithgastrointestinalstromaltumors AT antoniadimitrakopouloustrauss correlationofdynamicpetandgenearraydatainpatientswithgastrointestinalstromaltumors AT dirkkoczan correlationofdynamicpetandgenearraydatainpatientswithgastrointestinalstromaltumors AT leyunpan correlationofdynamicpetandgenearraydatainpatientswithgastrointestinalstromaltumors AT peterhohenberger correlationofdynamicpetandgenearraydatainpatientswithgastrointestinalstromaltumors |