Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models

Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models

<b>Background/Objectives:</b> Charcot first described ALS in 1869, but the specific mechanisms that mediate the disease pathology are still not clear. Intense research efforts have provided insight into unique neuroanatomical regions, specific neuronal populations and genetic association...

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Main Authors: Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Brain Sciences
Subjects:
motor neuron disease
neuroimmune
glial cells
neuromuscular junctions
microglia
astrocytes
Online Access:https://www.mdpi.com/2076-3425/15/1/84
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